Results 171 to 180 of about 311,030 (313)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Evidence Types, Credibility Factors, and Patterns or Soft Rules for Weighing Conflicting Evidence: Argument Mining in the Context of Legal Rules Governing Evidence Assessment [PDF]

, 2018
Vern R. Walker, Dina Foerster, Julia Monica Ponce, Matthew Rosen   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Preoperative Risk Stratification of Adnexal Masses Using the International Ovarian Tumor Analysis (IOTA) Simple Rules and Risk of Malignancy Index (RMI) 2: A Prospective Diagnostic Study From a Tertiary Centre in Southern India. [PDF]

Cureus
T K, Kathiresan S.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Towards evidence-based policy in melanoma screening and skin self-examination education. [PDF]

J Eur Acad Dermatol Venereol
Ozdemir SO, Shourick J.
europepmc   +1 more source

Federal Rules of Evidence [PDF]

, 2011
openaire   +1 more source

The Role and Current Status of IFRS in the Completion of National Accounting Rules – Evidence from Denmark

, 2017
Frank Thinggaard
openalex   +2 more sources

Experimental evidence of the spin selection rule in KLL Auger transition [PDF]

, 2001
D. J. Huang, Wen‐Bin Wu, C. F. Chang, J. Chen, S. C. Chung, L. H. Tjeng, C. T. Chen, Shin‐Guang Shyu, C. C. Wu   +8 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source