Results 51 to 60 of about 27,954 (304)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

أثر القيم الإسلامية في استنباط الحكم الشرعي (دراسة أصولية تطبيقية)

مجلة كلية العلوم الأسلامية
Our research titled "The Impact of Islamic Values on Deriving Legal Rulings: An Applied Jurisprudential Study" aids in understanding and practically applying Islamic law.
مها أحمد كمال, ثامر حمزة داود   +1 more
doaj   +1 more source

أحكام الجماع وفتاوى الجنس الشاذة في التلمود دراسة فقهية مقارنة [PDF]

مجلة کلية الاداب جامعة حلوان
الملخص : نرصد في هذه الدراسة أحكام الجماع في التلمود والوقوف على نقاط الاتفاق والاختلاف بين تلك الأحكام ونظائرها في كتب الفقه الإسلامي. كما نتعرف على فتاوى الجنس الشاذة التي يتبناها المجتمع الحريدي والتي تمثل المادة الخصبة وراء توجيه العلمانيين في ...
علاء تيسير احمد مهدي تيسير احمد مهدي
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Rights of Nature: Rivers That Can Stand in Court

Resources, 2018
An increasing number of court rulings and legislation worldwide are recognizing rights of nature to be protected and preserved. Recognizing these rights also entails the recognition that nature has the right to stand in court and to be represented for ...
Lidia Cano Pecharroman
doaj   +1 more source

Firewalls - Rules to Rule the Rules

, 2014
This paper was written in 2014 as part of a research project at scip AG, Switzerland. It was initially published online at https://www.scip.ch/en/?labs.20140403 and is available in English and German. Providing our clients with innovative research for the information technology of the future is an essential part of our company culture.
openaire   +2 more sources

Rule Rationality [PDF]

SSRN Electronic Journal, 2013
We study the strategic advantages of following rules of thumb that bundle different games together (called rule rationality) when this may be observed by one's opponent. We present a model in which the strategic environment determines which kind of rule rationality is adopted by the players.
Heller, Yuval, Winter, Eyal
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Relationship of the absolute rule of the Faqih with the role of time and place in ijtihad [PDF]

سپهر سیاست, 2019
The purpose of the present study was to explain the relationship between the jurisprudence of the jurisprudent and the role of time and place in ijtihad and present a new theoretical study on the use of jurisprudence's jurisprudence to facilitate ...
afsaneh torkashvand, Mahmood Ghayoom zadeh, Abbas Ali Heidari   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source