Results 51 to 60 of about 108,565 (259)

TempoCave: Visualizing Dynamic Connectome Datasets to Support Cognitive Behavioral Therapy [PDF]

, 2019
We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of different regions ...
Ajilore, Olusola A, Forbes, Angus G, IEEE, Leow, Alex, Thomas, Manu Mathew, Xu, Ran   +5 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

State rumination predicts inhibitory control failures and dysregulation of default, salience, and cognitive control networks in youth at risk of depressive relapse: Findings from the RuMeChange trial

Journal of Affective Disorders Reports
Background: Trait rumination is a habitual response to negative experiences that can emerge during adolescence, increasing risk of depression. Trait rumination is correlated with poor inhibitory control (IC) and altered default mode network (DMN) and ...
Henrietta Roberts, Mindy Westlund Schreiner, Stephanie Pocius, Alina K. Dillahunt, Brian Farstead, Daniel Feldman, Katie L. Bessette, Erin A. Kaufman, Will Slattery, Rachel H. Jacobs, David Jago, Sheila E. Crowell, Edward R Watkins, Scott A. Langenecker   +13 more
doaj   +1 more source

Hemodynamic profiles of functional and dysfunctional forms of repetitive thinking [PDF]

, 2016
Background: The ability of the human brain to escape the here and now (mind wandering) can take functional (problem solving) and dysfunctional (perseverative cognition) routes.
Brosschot, Jos F., Lonigro, Antonia, Medea, Barbara, Ottaviani, Cristina, Thayer, Julian F., van Diest, Ilse   +5 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Relationship among occupational stress, work-related rumination, and sleep quality in emergency medical dispatchers in some areas of China

环境与职业医学
BackgroundThe increasing demand for emergency services coupled with the special working environment has exacerbated occupational stress and work-related rumination among emergency medical dispatchers, which is noteworthy for its impact on dispatchers ...
Xiaoying SHI, Qing ZHANG, Zhongyuan YAN, Qin ZHANG, Dan XU   +4 more
doaj   +1 more source

Negative emotional events that people ruminate about feel closer in time.

PLoS ONE, 2015
Rumination is intrusive, perseverative cognition. We suggest that one psychological consequence of ruminating about negative emotional events is that the events feel as though they happened metaphorically "just yesterday".
Ewa Siedlecka, Miriam M Capper, Thomas F Denson   +2 more
doaj   +1 more source

A Cross-Cultural Look at Co-rumination, Self-Disclosure, Friendship, Relational Concerns and Emotional Adjustment [PDF]

, 2013
Rose (2002) first defined co-rumination as extensive problem-focused talk, and it has been found to be associated with both depression/anxiety and friendship quality. However, our understanding of co-rumination is limited by an exclusive focus on Western
Brown, Mengni T., Tompkins, Tanya L.
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source