Results 201 to 210 of about 1,171,960 (265)

Efficacy and safety of standalone middle meningeal artery embolization for chronic subdural hematoma: a single-center retrospective cohort study. [PDF]

BMC Neurol
Xie D.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes. [PDF]

Proc Natl Acad Sci U S A
Whitney ON, Dailey GM, McKenna JK, Darzacq X, Tjian R.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Blue rubber bleb nevus syndrome complicated with esophageal squamous carcinoma: A case report with robotic-assisted resection and literature review. [PDF]

J Int Med Res
Pan Y, Zhu Z, Cai J.
europepmc   +1 more source

Benchmarking Radiation Transport Monte Carlo Simulations with MCNP and Geant4 Using High Performance Computing. [PDF]

Health Phys
Moats K, Desrosiers M, Linton G, Wood R.
europepmc   +1 more source

Effects of ciprofol versus propofol sedation on hypoxaemia and hypotension in elderly patients undergoing bidirectional endoscopy: protocol for a randomized controlled trial. [PDF]

Front Med (Lausanne)
Fei Y, Gu M, Li X, Zheng L, Yu Y, Chen Z.   +5 more
europepmc   +1 more source

Effectiveness of digital inhaled therapy management and respiratory muscle training in moderate to severe COPD patients: study protocol for a randomized controlled, assessor-blinded, multicenter trial. [PDF]

Trials
Xu Y, Zhou M, Hu X, Pan L, Chen F, Chen B, Cao Q, Jiang T, Zhu J, Li N, Jiang A, Lian C, Chen Z, Ge H.   +13 more
europepmc   +1 more source

Efficacy and safety of long-acting injectable paliperidone palmitate 1-month and 3-month formulations in the maintenance treatment of schizophrenia: a single-arm, open-label, interventional study in Rwandan healthcare settings. [PDF]

BMJ Open
Bizoza R, Mehawej J, Musoni-Rwililiza E, Alphs L, Turkoz I, Sun L, Killion L, Decotelli-Mendes C, Knight RK.   +8 more
europepmc   +1 more source

Protocol to benchmark and evaluate the status of imbalance measure using correlation, data complexity, and ablation analyses. [PDF]

STAR Protoc
Pivin-Bachler JR, van den Broek EL.
europepmc   +1 more source