Results 131 to 140 of about 3,821,420 (285)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Acute effects of negative heel shoes on perceived pain and knee biomechanical characteristics of runners with patellofemoral pain

Journal of Foot and Ankle Research
Background To determine the effects of negative heel shoes on perceived pain and knee biomechanical characteristics of runners with patellofemoral pain (PFP) during running.
Yu Gu, Zhiyi Zheng, Quanshou Zeng, Chen Yang, Yu Song, Xianglin Wan   +5 more
doaj   +1 more source

Out and running: gay and lesbian candidates, elections, and policy representation

, 2011
Hugo Bouvard
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Accuracy of self-reported foot strike pattern detection among endurance runners

Frontiers in Sports and Active Living
IntroductionFoot strike pattern is often associated with running related injury and the focus of training and rehabilitation for athletes. The ability to modify foot strike pattern depends on awareness of foot strike pattern before being able to attempt ...
Heather K. Vincent, Kyle Coffey, Aiden Villasuso, Kevin R. Vincent, Sharareh Sharififar, Lydia Pezzullo, Ryan M. Nixon   +6 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Advanced Footwear Technology in Non-Elite Runners: A Survey of Training Practices and Reported Outcomes

Sports
Background: Advanced footwear technology (AFT) has gained popularity among non-elite runners due to its potential benefits in training and competition.
Matteo Bonato, Federica Marmondi, Emanuela Luisa Faelli, Chiara Pedrinelli, Luigi Ferraris, Luca Filipas   +5 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Greek pentathletes: the path to victory

RUDN Journal of World History
The purpose of the study is to find out how the Greek pentathlon was organized at the Panhellenic Games as well as what was the sequence of competitions in it, whether the rules of its organization differed at the Panhellenic and the local Games, how the
Tatiana B. Gvozdeva
doaj   +1 more source