Results 101 to 110 of about 4,292,819 (347)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

A comparative study on ecological risk assessment of some potentially toxic elements accumulation in surface sediment of stagnant and running water ecosystems in Meriç delta wetland, Turkish Thrace [PDF]

open access: yesJournal of the Serbian Chemical Society
This study determined arsenic, chromium, cadmium, copper, zinc, nickel and lead concentrations in the sediment of the lake and river and evaluated their ecological risk profile and compared the ecological risk profile of some potentially toxic elements ...
Aydin Gazel Burcu
doaj   +1 more source

Assessment of a rail vehicle running with the damaged wheel on a ride comfort for passengers

open access: yes, 2018
In certain circumstances rail vehicles wheels can be during operation damaged. Then, the profile of wheels is no longer circular, but it is changed depending on the type and severity of defects.
J. Dižo   +3 more
semanticscholar   +1 more source

Computer aided simulation analysis for wear investigation of railway wheel running surface

open access: yesDiagnostyka, 2019
In railway applications wear prediction in the wheel–rail interface is a fundamental matter in order to study problems such as wheel lifespan and the evolution of vehicle dynamic characteristic with time.
P. Droździel   +2 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

基于行驶仿真试验的行星减速机动力学仿真

open access: yesJixie chuandong, 2006
The static strength theory applied in the design process of the planetary reducer can’t reflect the dynamic loads suffered by it,so the faults of the planetary reducer are more than the imagination in running process.In order to solve the problem ...
杜秀菊, 王兴贵
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dynamic Inspection System for Wheel Profile of High-speed Railway Vehicles

open access: yes机车电传动, 2017
Measuring wheel profile parameters is very important for the safety of running trains. Inspection of wheel profile parameters with laser light image was the mainstream technology.
YANG Hui
doaj  

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