Results 101 to 110 of about 1,144,325 (277)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Applied SciencesThe aim of the current investigation was to examine the locomotor performance profile of elite ladies Gaelic football (LGF) players in relation to playing position and quarters of play.
Shane Malone +5 more
doaj +1 more source
Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise
Frontiers in Microbiology, 2018 A few animal studies have shown that wheel running could reverse an unhealthy status by shifting the gut microbial composition, but no investigations have studied the effect of endurance running, such as marathon running, on human gut microbial ...
Xia Zhao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A comparative study on ecological risk assessment of some potentially toxic elements accumulation in surface sediment of stagnant and running water ecosystems in Meriç delta wetland, Turkish Thrace [PDF]
Journal of the Serbian Chemical SocietyThis study determined arsenic, chromium, cadmium, copper, zinc, nickel and lead concentrations in the sediment of the lake and river and evaluated their ecological risk profile and compared the ecological risk profile of some potentially toxic elements ...
Aydin Gazel Burcu
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Jixie chuandong, 2006 The static strength theory applied in the design process of the planetary reducer can’t reflect the dynamic loads suffered by it,so the faults of the planetary reducer are more than the imagination in running process.In order to solve the problem ...
杜秀菊, 王兴贵
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Discrete Dynamical Systems Embedded in Cantor Sets
, 2006 While the notion of chaos is well established for dynamical systems on manifolds, it is not so for dynamical systems over discrete spaces with $ N $ variables, as binary neural networks and cellular automata.
Alberto Verjovsky +11 more
core +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source