Results 111 to 120 of about 1,144,325 (277)

Dynamic Inspection System for Wheel Profile of High-speed Railway Vehicles

机车电传动, 2017
Measuring wheel profile parameters is very important for the safety of running trains. Inspection of wheel profile parameters with laser light image was the mainstream technology.
YANG Hui
doaj  

Force-Velocity Profile in Middle- and Long-Distance Athletes: Sex Effect and Impact on Endurance Performance Determinants

Applied Sciences
Background: Muscle strength plays a critical role in the performance of middle- and long-distance athletes. However, the vertical force–velocity (F–V) profile has not been studied in this population.
Violeta Muñoz de la Cruz, Fernando González-Mohíno, Sergio Rodríguez-Barbero, Fernando Valero, José María González-Ravé   +4 more
doaj   +1 more source

Analytical Determination of the Optimal Temperature Profiles for the Reactions with Parallel Deactivation of Enzyme Encapsulated Inside Microorganisms Cells [PDF]

, 2012
A batch biotransformation process running in the presence of microorganisms cells revealing a specified enzyme activity has been considered. The parallel deactivation of enzyme has been taken into account.
I. Grubecki
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Inflation, cold dark matter, and the central density problem

, 2002
A problem with high central densities in dark halos has arisen in the context of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is often justified by appealing to the inflation scenario, inflationary models with mild deviations
A. Borriello, A. Burkert, A.A. Klypin, A.A. Starobinsky, A.D. Linde, A.I. Belesev, A.V. Kravtsov, Andrew R. Zentner, B. Moore, B. Moore, B. Moore, C. Bento, C. Firmani, C. Lacey, C.-P. Ma, C.L. Bennett, C.R. Keeton, Ch. Weinheimer, D. Polarski, D.G. York, D.H. Lyth, D.J. Eisenstein, D.J. Eisenstein, D.N. Abdurashitov, D.N. Spergel, D.S. Salopek, D.S. Salopek, E. Gaztañaga, E. Pierpaoli, E.D. Carlson, E.D. Stewart, E.D. Stewart, E.D. Stewart, E.D. Stewart, E.F. Bunn, E.F. Bunn, F.C. van den Bosch, G. Lazarides, G.L. Bryan, G.R. Blumenthal, I.J. Grivell, J. E. Lidsey, J. Lesgourgues, J. Silk, J. Sommer-Larsen, J.A. Adams, J.E. Lidsey, J.F. Navarro, J.F. Navarro, J.F. Navarro, J.F. Navarro, J.J. Binney, J.J. Dalcanton, J.M. van der Hulst, J.R. Bond, J.S. Bullock, J.S. Bullock, James S. Bullock, L. Covi, L. Covi, L. Silberman, L.A. Kofman, L.A. Kofman, L.F. Abbott, M. Altmann, M. Fukugita, M. Kamionkowski, M. Kaplinghat, P. Bode, P. Colín, P. McDonald, P.J. Steinhardt, P.J.E. Peebles, P.J.E. Peebles, Q.R. Ahmad, Q.R. Ahmad, R. Flores, R.A.C. Croft, R.H. Wechsler, R.N. Mohapatra, S. Bildhauer, S. Blais-Ouellette, S. Borgani, S. Côté, S. Dodelson, S. Hannestad, S. M. Leach, S.S. McGaugh, T. Matos, T. Matos, V.M. Lobashev, V.P. Debattista, V.R. Eke, W. Hampel, W. Hu, W. Hu, W.B. Lin, W.J.G. de Blok, W.J.G. de Blok, W.J.G. de Blok, W.W.M. Allison, X. Wang, Y. Fukuda, Y. Jing, Y.-S. Fukuda, Y.P. Jing, Ø. Elgarøy   +106 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Running economy and cytokines: what the influence of IL-6 and IL-10? [PDF]

, 2014
Introduction: During the exercise performing the muscle produce cytokines, named “myokines”. These molecules show autocrine, paracrine and endocrine effects. One of them IL-6 demonstrates both pro and anti-inflammatory actions.
Bachi, Andre, Luna, Luiz, Jr., Paiva, Roberta, Sierra, Ana, Vaisberg, Mauro, Vaisberg, Pedro   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Automatic Detection of the Running Surface of Railway Tracks Based on Laser Profilometer Data and Supervised Machine Learning

Sensors
The measurement of the longitudinal rail profile is relevant to the condition monitoring of the rail infrastructure. The running surface is recognizable as a shiny metallic area on top of the rail head. The detection of the running surface is crucial for
Florian Mauz, Remo Wigger, Alexandru-Elisiu Gota, Michal Kuffa   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source