Results 111 to 120 of about 59,095 (257)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg +8 more
wiley +1 more source
Mechanistic Digital Model for Real‐Time Monitoring and Optimization of Adenovirus Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adenoviral vectors are a critical vaccine platform, with billions of vaccine doses administered during the COVID‐19 pandemic. In addition, they are promising therapeutics for cancer treatment. To advance their manufacturing, real‐time monitoring of adenovirus production is essential for process optimization, yield improvement, and product ...
Xingge Xu +4 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT A method to select Escherichia coli citrate synthase variants having reduced activity was developed based initially on the increased generation of acid, observed visually by prolonged color change in the pH indicator bromocresol purple. Five hundred fifty‐two potential variants were isolated and each were cultured on glucose as sole carbon ...
Jeffrey K. Dodelin +3 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The glutamine synthetase expression system is widely used for therapeutic protein biomanufacturing in Chinese hamster ovary (CHO) cells. Here, we present the design of an enhanced glutamine synthetase vector for generating CHOK1SV GS‐KO stable pools that produce recombinant proteins at multigram‐per‐liter levels. We first developed a synthetic
Yusuf B. Johari +11 more
wiley +1 more source
Issue Construals and Corporate Water Stewardship
Business Strategy and the Environment, EarlyView.ABSTRACT In the face of mounting environmental and social pressures, the importance of responsible corporate water stewardship (CWS) should be evident, yet not all businesses are taking water management issues seriously. The aim of this study is to explore why differences in CWS persist, especially within industries facing similar resource challenges ...
Daina Mazutis +3 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Sustainability certifications are increasingly embedded in the governance and competitiveness of the wine sector, yet their strategic role remains under‐theorised. This study conceptualises certifications as multidimensional strategic mechanisms and conducts a comparative analysis of 50 schemes used in the global wine industry.
Alexy Apolo‐Romero +2 more
wiley +1 more source
Biodiversity Strategies in Action—Empirical Evidence From the Food Value Chain
Business Strategy and the Environment, EarlyView.ABSTRACT There is an increasing need for better understanding of firm activities that contribute to biodiversity preservation. Panwar, Ober, and Pinkse offer a valuable typology of corporate biodiversity protection strategies based on temporal and spatial dimensions, namely, the preloss (proactive) strategies of conservation and compensation, and the ...
Joanna Scott‐Kennel +2 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Biodiversity underpins ecosystem functioning and the provision of ecosystem services, yet it continues to decline due to intensive agriculture, pollution, habitat loss and climate change. Although ecolabels are increasingly used to communicate sustainability attributes and influence consumer choices, their role in addressing biodiversity ...
Marzieh Aminravan +4 more
wiley +1 more source
An Essay on Runoff Ratio and Runoff Height
Journal of Japanese Association of Hydrological Sciences, 2001 openaire +2 more sources