Results 251 to 260 of about 1,736,965 (307)

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj   +16 more
wiley   +1 more source

Fluorescent and Chemiluminescent Dyes with Aryl Phthalimide and Aryl Luminol Chromophores

open access: yesChemPhotoChem, EarlyView.
A series of photo‐active phthalimides and luminols is prepared by an arylation method from a key precursor. Significant stereoelectronic correlation of the aromatic substituents with the photophysical properties is documented. A new arylated luminol derivative shows a more than three times higher ΦCL than the parent luminol.
Ben C. Bimberg   +9 more
wiley   +1 more source

The Interplay of Public Administration and Community Resilience During the COVID‐19 Pandemic—A Rapid Scoping Review

open access: yesConflict Resolution Quarterly, EarlyView.
ABSTRACT This rapid scoping review examines the interplay between public administration and community resilience during the COVID‐19 pandemic, focusing on the type of research conducted, emerging themes in resilience studies, and key lessons learned. The findings show that research in the Global North has primarily examined resilience at the city level,
Daniela Gröschke
wiley   +1 more source

A Meta Analytical Study of Cultural Conditions Moderating the Relationship Between Board Diversity and CSR Disclosure

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Studies on the relationship between board diversity and CSR disclosure have shown mixed results. This study investigates the relationship between board diversity attributes and CSR disclosure, as well as the various cultural conditions influencing board diversity–CSR disclosure relationships through meta‐analysis based on data from 45 ...
Waris Ali   +2 more
wiley   +1 more source

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