Results 261 to 270 of about 2,069,462 (359)

10. Russian Federation [PDF]

open access: yesYearbook of International Environmental Law, 2011
openaire   +2 more sources

Tethering Efficiency of Reversible Addition‐Fragmentation Chain Transfer‐Synthesized Styrene Maleic Acid Polymers and Associated Styrene Maleic Acid Lipid Nanoparticles on Gold Surfaces

open access: yesChemPlusChem, EarlyView.
Styrene maleic acid lipid nanoparticles (SMALPs) comprised of diblock styrene maleic acid (SMA) copolymers readily tether to gold surfaces. This binding is enhanced when the diblock SMA is functionalized with a trithiocarbonate and hydrophilic (Z)‐end‐group generated through the reversible addition‐fragmentation chain transfer polymerization process ...
Michelle D. Farrelly   +3 more
wiley   +1 more source

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj   +16 more
wiley   +1 more source

Phase-1 study of vamotinib (PF-114), a 3rd generation BCR::ABL1 tyrosine kinase-inhibitor, in chronic myeloid leukaemia. [PDF]

open access: yesAnn Hematol
Turkina A   +19 more
europepmc   +1 more source

Exposure‐Response Relationships for Axatilimab in Patients with Chronic Graft‐Versus‐Host Disease

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Axatilimab, a high‐affinity humanized monoclonal antibody that targets colony‐stimulating factor 1 receptor, is approved for the treatment of chronic graft‐versus‐host disease (cGVHD). Here, we describe the exposure‐response relationships for efficacy and safety in patients with cGVHD who received axatilimab.
Yan‐ou Yang   +7 more
wiley   +1 more source

Fluorescent and Chemiluminescent Dyes with Aryl Phthalimide and Aryl Luminol Chromophores

open access: yesChemPhotoChem, EarlyView.
A series of photo‐active phthalimides and luminols is prepared by an arylation method from a key precursor. Significant stereoelectronic correlation of the aromatic substituents with the photophysical properties is documented. A new arylated luminol derivative shows a more than three times higher ΦCL than the parent luminol.
Ben C. Bimberg   +9 more
wiley   +1 more source

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