Results 51 to 60 of about 41,278 (99)

Who do I want in my team: Social avoidance of high qualified partners in depression and social anxiety

Journal of Affective Disorders Reports, 2022
Background: Social difficulties are inherent to social anxiety and are critical in depression. A key feature in both disorders is social avoidance, which leads to the loss of opportunities and precludes from improving social abilities.
L. Uriarte-Gaspari, A. Acuña, S. Morales, G. Fernández-Theoduloz, V. Paz, A. Pérez, Á. Cabana, V.B. Gradin   +7 more
doaj   +1 more source

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

PLoS ONE, 2015
Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation.
B. Probst, Isaac Treviño, Lyndsey McCauley, R. Bumeister, I. Dulubova, W. Wigley, D. Ferguson   +6 more
semanticscholar   +1 more source

The relationship between cognitive flexibility, depression, and work performance: Employee assessments using cognitive flexibility tests

Journal of Affective Disorders Reports, 2022
Background: Cognitive flexibility is a frontal lobe function, and some scholars have indicated that it is linked to depression. The Cognitive Flexibility Test (CFT) is a neuropsychological test that can easily and promptly measure cognitive flexibility ...
Toshiki Fukuzaki, Shinya Takeda
doaj   +1 more source

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

OncoTargets and Therapy, 2017
Background Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the ...
B. Creelan, D. Gabrilovich, J. Gray, Charles C. Williams, T. Tanvetyanon, E. Haura, J. Weber, G. Gibney, J. Markowitz, J. Proksch, S. Reisman, M. McKee, M. Chin, C. Meyer, S. Antonia   +14 more
semanticscholar   +1 more source

408 Cases of Genital Ambiguity Followed by Single Multidisciplinary Team during 23 Years: Etiologic Diagnosis and Sex of Rearing

International Journal of Endocrinology, 2016
Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center.
Georgette Beatriz De Paula, B. A. Barros, Stela Carpini, Bruna J Tincani, T. Mazzola, Mara Sanches Guaragna, C. S. C. Piveta, L. C. de Oliveira, J. Andrade, Guilherme Guaragna-Filho, Pedro Perez Barbieri, Nathalia Montibeler Ferreira, M. Miranda, E. Gonçalves, A. Morcillo, N. Viguetti-Campos, S. Lemos-Marini, R. B. D. P. Silva, A. P. Marques-de-Faria, M. de Mello, A. Maciel-Guerra, G. Guerra‐Júnior   +21 more
semanticscholar   +1 more source

Are body weight changes depressogenic? Even intentional weight loss correlates with increased depressive symptomatology among overweight or obese adults in the United States

Journal of Affective Disorders Reports, 2022
Background: Relations of body weight with depressive symptomatology are complex and incompletely understood. Obesity and depression are clearly linked, but weight loss has correlated with both lower and higher depressive symptomatology in past research ...
Jeffrey R. Vittengl
doaj   +1 more source

Subjective cognitive impairment and its relationship to sleep impairment, anxiety severity, and depressive symptoms in individuals with bipolar disorder

Journal of Affective Disorders Reports, 2022
Objectives: Individuals with bipolar disorder commonly report cognitive impairment which is associated with several psychosocial factors (e.g., mood symptoms). Within this study, we investigated the relationship between these psychosocial factors and the
Jennifer E. Siegel-Ramsay, Bryan Wu, Mark Bond, David Spelber, Karl S. Chiang, Teresa Lanza di Scalea, Sam J. Collier, Tawny Smith, Leyna Nunez, Ersten Fuller, Stephen M. Strakowski, Elizabeth Lippard, Jorge R.C. Almeida   +12 more
doaj   +1 more source

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BMC Dermatology, 2015
BackgroundTopical application of the synthetic triterpenoid RTA 408 to rodents elicits a potent dermal cytoprotective phenotype through activation of the transcription factor Nrf2.
S. Reisman, A. Goldsberry, Chun-Yue I. Lee, Megan O’Grady, J. Proksch, K. Ward, C. Meyer   +6 more
semanticscholar   +1 more source

MovieQA: Understanding Stories in Movies through Question-Answering [PDF]

Computer Vision and Pattern Recognition, 2015
We introduce the MovieQA dataset which aims to evaluate automatic story comprehension from both video and text. The dataset consists of 14,944 questions about 408 movies with high semantic diversity.
Makarand Tapaswi, Yukun Zhu, R. Stiefelhagen, A. Torralba, R. Urtasun, S. Fidler   +5 more
semanticscholar   +1 more source

Depression onset and its association with community HIV prevalence: A geospatial and panel analyses of nationally representative South African data, 2015–2017

Journal of Affective Disorders Reports, 2022
The scaling up of antiretroviral therapy services over the past decades has led to a remarkable reduction in HIV infections and HIV-related deaths in South Africa (SA).
Kwabena Asare, Andrew Tomita, Nigel Garrett, Rob Slotow, Jonathan K Burns, Frank Tanser, Diego F. Cuadros   +6 more
doaj   +1 more source