Results 61 to 70 of about 41,762 (99)

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

PLoS ONE, 2015
Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation.
B. Probst, Isaac Treviño, Lyndsey McCauley, R. Bumeister, I. Dulubova, W. Wigley, D. Ferguson   +6 more
semanticscholar   +1 more source

Phase-based psychological interventions for complex post-traumatic stress disorder: A systematic review

Journal of Affective Disorders Reports, 2023
Debate is ongoing as to whether phase-based or single-phase interventions should be recommended for Complex Post-Traumatic Stress Disorder (CPTSD). This is a systematic review of the evidence for phase-based interventions for CPTSD, the impact of Phase 1
Ruth Jessica Darby, Emily P Taylor, Mariana Segovia Cadavid   +2 more
doaj   +1 more source

Theta-burst stimulation for the treatment of unipolar and bipolar depression

Journal of Affective Disorders Reports, 2023
Recently, we have approached the recent systematic review conducted by Qin et al. (2023) (doi:10.1016/j.jad.2023.08.065) on the efficacy and safety of bilateral theta burst stimulation (TBS) for patients experiencing acute unipolar or bipolar depressive ...
Li Li, Chaomeng Liu
doaj   +1 more source

The French version of the surgical fear questionnaire is a valid and reproducible score to assess the fear of surgery

Journal of Affective Disorders Reports, 2023
Backround: The Surgical Fear Questionnaire (SFQ) is a reliable tool to measure fear of surgery. It is the only self-reporting questionnaire that is suitable for all adult surgeries.
L. EL Otmani, M.H. Sandiford, E. Valentin, C. Menigaux, T. Bauer, A. Hardy   +5 more
doaj   +1 more source

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BMC Dermatology, 2015
BackgroundTopical application of the synthetic triterpenoid RTA 408 to rodents elicits a potent dermal cytoprotective phenotype through activation of the transcription factor Nrf2.
S. Reisman, A. Goldsberry, Chun-Yue I. Lee, Megan O’Grady, J. Proksch, K. Ward, C. Meyer   +6 more
semanticscholar   +1 more source

Search of brain-enriched proteins in salivary extracellular vesicles for their use as mental disease biomarkers: A pilot study of the neuronal glycoprotein M6a

Journal of Affective Disorders Reports, 2020
Background: Mental disorders affect millions of people worldwide. Their etiology is complex and the fact that the main effects occur in the brain hampers biochemical diagnosis.
Melisa C. Monteleone, Silvia C. Billi, Luciano Viale, Natalia P. Catoira, Alberto C. Frasch, Marcela A. Brocco   +5 more
doaj   +1 more source

Linking resting state metabolite concentrations in the dorsal anterior cingulate cortex to response inhibition in OCD, a combined fMRI-MRS study

Journal of Affective Disorders Reports, 2023
Introduction: Obsessive-compulsive disorder (OCD) has been associated with abnormal brain activation in regions related to response inhibition, such as the dorsal anterior cingulate cortex (dACC), as well as dysregulation of the glutamate system.
Niels T. de Joode, Anders L. Thorsen, Chris Vriend, Petra J.W. Pouwels, Anton J.L.M. van Balkom, Kristen Hagen, Olga T. Ousdal, Bjarne Hansen, Gerd Kvale, Odile A. van den Heuvel   +9 more
doaj   +1 more source

Reduced heart rate variability is associated with vulnerability to depression

Journal of Affective Disorders Reports, 2020
Background: Heart rate variability (HRV) mirrors cardiac autonomic modulation, an index of well-being. Reduced HRV has been reported in depression, but few studies investigated HRV in individuals at-risk of or remitted from a full-blown depressive ...
Carola Dell’Acqua, Elisa Dal Bò, Simone Messerotti Benvenuti, Daniela Palomba   +3 more
doaj   +1 more source

The potential of physical activity and technology interventions to reduce anxiety in older adults

Journal of Affective Disorders Reports, 2023
Background: Older adults have low levels of mental health literacy relating to anxiety, which may explain why they delay or do not seek help. Emerging evidence supports effectiveness of lifestyle interventions, including physical activity (PA), in ...
Terence W.H. Chong, Eleanor Curran, Jenny Southam, Christina Bryant, Kay L Cox, Kathryn A. Ellis, Kaarin J. Anstey, Anita Goh, Nicola T Lautenschlager   +8 more
doaj   +1 more source

Evaluation of a transdiagnostic treatment for adolescents with comorbid anxiety and depression

Journal of Affective Disorders Reports, 2020
Background: Evidence suggests that adolescents with comorbid anxiety and depression are a high-risk group in terms of symptom severity, life quality and prognosis, with unique treatment needs compared to their peers who meet criteria for a single ...
Carolyn A. Schniering, Ronald M. Rapee
doaj   +1 more source