Results 141 to 150 of about 4,353,984 (267)

Flea parasitism in wild mammals in the metropolitan region of Sorocaba, São Paulo, Brazil. [PDF]

Braz J Vet Med, 2023
Teixeira RHF, da Costa ALM, Gonzaga CRR, Matos FN, de Medeiros MA, Leandro SFS, Von Matheus R, Bellotti MA, Lima BF, Sakamoto CAM, Barros LA.   +10 more
europepmc   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

TRANSPLANTES DE CÉLULAS-TRONCO HEMATOPOIÉTICAS PARA O TRATAMENTO DE ANEMIA FALCIFORME EM PEDIATRIA

Hematology, Transfusion and Cell Therapy, 2020
R.V. Gouveia, V.C. Ginani, G. Zamperlini, C.M.C. Zanchetta, D. Lutti, E.J.C.F. Souto, N.A. Pereira, M. Dantas, J.F. Marques, A. Seber   +9 more
doaj   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

TRATAMENTO DE LEUCEMIA LINFÓIDE AGUDA PEDIÁTRICA RECIDIVADA APÓS TRANSPLANTE ALOGÊNICO DE CÉLULAS-TRONCO HEMATOPOIÉTICAS COM BLINATUMOMAB

Hematology, Transfusion and Cell Therapy, 2020
G. Zamperlini, V.C. Ginani, R.V. Gouveia, L.D.S. Domingues, C.N.M. Breviglieri, J.F. Marques, F.V.B. Santos, C.F. Andrade, M.G. Matos, A. Seber   +9 more
doaj   +1 more source

Microfiltration (MF) and Ultrafiltration (UF) for Sewage and Surface Water Concentration for SARS‐CoV‐2 and Other Enveloped Viruses' Detection in Wastewater‐Based Epidemiology (WBE)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT This study objective was to evaluate hollow fiber membranes for concentration of enveloped enteric viruses in sewage and surface water samples. Microfiltration (MF, 0.2 µm nominal pore size) and ultrafiltration (UF, 100 kDa molecular weight cut‐off) hollow fiber membranes were compared for the concentration of the bovine respiratory syncytial ...
Rodrigo Almeria Ragio, Rodrigo de Freitas Bueno, Roseli Frederigi Benassi, Eduardo Lucas Subtil   +3 more
wiley   +1 more source

Factors associated with visual function among computer-based administrative workers: a Brazilian cross-sectional study. [PDF]

Rev Bras Med Trab, 2023
Sá EC, Martinez MC, Silva-Junior JS, Fischer FM.   +3 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Navigating the Double Edge of Product‐Service Systems: User Behavior, Adoption, and Rebound Effects

Business Strategy and the Environment, EarlyView.
ABSTRACT Product‐service systems (PSS) have been considered a promising approach to operationalizing the circular economy. Although many studies have outlined the potential sustainability gains of PSS solutions, it is still unclear what factors drive PSS adoption and how behavioral changes result in rebound effects, undermining their potential ...
Marina Fernandes Aguiar, Daniel Guzzo, Janaina Mascarenhas, Daniela C. A. Pigosso   +3 more
wiley   +1 more source

Microbial keratitis in Sao Paulo, Brazil: a 10-year review of laboratory results, epidemiological features, and risk factors. [PDF]

Arq Bras Oftalmol, 2023
Kase C, Boppré YT, Rocchetti TT, Yu MCZ, Fernandes AG, Hofling-Lima AL.   +5 more
europepmc   +1 more source