Results 11 to 20 of about 19,735 (171)
Hematology, Transfusion and Cell Therapy, 2021 Introdução: A infusão de leucócitos do doador (DLI) pode ser uma opção terapêutica para pacientes com recidiva da doença de base após TCTH. A dose celular varia com a doença de base, tipo de doador e presença de DECH.
RV Gouveia +14 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
ATENDIMENTO PADRONIZADO PARA PACIENTES IMUNO-HEMATOLÓGICOS COMPLEXOS
Hematology, Transfusion and Cell TherapyDevido a expansão do Grupo VITA São Paulo (SP), o setor de imuno-hematologia foi reestruturado para melhor atender pacientes e doadores, separado em agência transfusional que realiza os testes pré transfusionais básicos e em laboratório central de imuno,
C Altobeli +9 more
doaj +1 more source
RECAÍDA DE LINFOMA DE HODGKIN EM SISTEMA NERVOSO CENTRAL, UMA APRESENTAÇÃO ATÍPICA
Hematology, Transfusion and Cell Therapy, 2023 Objetivo: Relatar uma apresentação rara de recaída de linfoma de Hodgkin (LH) em sítio extranodal atípico. Material e métodos: As informações deste trabalho foram obtidas da revisão do prontuário e revisão da literatura.
AM Carvalho +9 more
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Brazilian Journal of Infectious DiseasesIntrodução: A resistência microbiana é um grave problema de saúde pública e está associada ao aumento do tempo de internação, elevados custos e de mortalidade dos pacientes.
Luciana de Oliveira Matias +8 more
doaj +1 more source
Hematology, Transfusion and Cell Therapy, 2023 Introdução/Objetivo: Pacientes com leucemia aguda comumente apresentam, em sua evolução natural, complicações infecciosas pulmonares, sendo a broncoscopia uma ferramenta valiosa de acordo com dados mais recentes da literatura.
JVR Oliveira +9 more
doaj +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source