Results 261 to 270 of about 2,382,522 (312)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Mulching Increases Water Use Efficiency, Production and Profitability in Forage Cactus–Maize Intercropping Systems

open access: yesIrrigation and Drainage, EarlyView.
ABSTRACT This study evaluated the growth, forage production, soil water balance, water indices, biological efficiency and competitive capacity of forage cactus and maize in monoculture and intercropping, with or without mulch. The experiment was conducted in Serra Talhada, Pernambuco, Brazil, using the cactus clone ‘Orelha de Elefante Mexicana’ (OEM ...
Kaique Renan da Silva Salvador   +13 more
wiley   +1 more source

The São Paulo declaration on One Health: Brazil's path forward to face intersectoral health challenges. [PDF]

open access: yesOne Health Outlook
Soeiro-Barbosa D   +23 more
europepmc   +1 more source

Artificial Neural Networks for Defining the Operational Parameters of Sand Filters for Irrigation

open access: yesIrrigation and Drainage, EarlyView.
ABSTRACT The difficulty in defining the working configuration during the operation of sand filters arises from the complexity of the relationships among the variables in the filtration and backwashing processes. The objective was to use artificial neural networks to model the pressure loss and removal efficiency of filtration in a commercial sand ...
Mádilo Lages Vieira Passos   +4 more
wiley   +1 more source

O funil na educação em São Paulo – Cartum do Ohi

open access: yesRevista Espaço Acadêmico, 2009
José Luiz Ohi
doaj  

Knowledge, Attitudes, Practices and Perceptions of the Eco-Bio-Social Determinants of Dengue Transmission in São Paulo, Brazil: A Mixed-Methods Study. [PDF]

open access: yesTrop Med Int Health
Barkhad A   +10 more
europepmc   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro   +5 more
wiley   +1 more source

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