Results 201 to 210 of about 2,922,047 (250)

Automatic Segmentation of Medial Temporal Lobe Subregions in Multi-Scanner, Multi-Modality Magnetic Resonance Imaging of Variable Quality. [PDF]

open access: yesHippocampus
Li Y   +11 more
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

open access: yesChemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito   +3 more
wiley   +1 more source

A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl‐Aryl Ether Formation in the Biosynthesis of Emestrin

open access: yesChemistry – A European Journal, EarlyView.
Conversion of emestrin J (5) to emestrin (1) by three P450 enzymes from the cluster (eme) in Emericella quadrilineata. EmeO acts as a bifunctional enzyme for the construction of the 15‐membered lactone ring via an aryl‐aryl ether bond formation and simultaneous hydroxylation between phenolic and nonphenolic aromatic rings, while EmeE and EmeR install ...
Yu‐Chuan Chen   +3 more
wiley   +1 more source

Acid‐Catalyzed Synthesis of Si‐Stereogenic Silanes

open access: yesChinese Journal of Chemistry, EarlyView.
Si‐stereogenic silanes are important structural motifs in chemical synthesis, medicinal chemistry, and materials science. However, their catalytic enantioselective synthesis has largely relied on transition‐metal catalysts. Recently, Brønsted acids have been developed as promising alternatives.
Jung Tae Han, Benjamin List
wiley   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

open access: yesCytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński   +2 more
wiley   +1 more source

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