Results 101 to 110 of about 193,160 (256)

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

PRONÓSTICO DE LA DEMANDA MENSUAL DE ELECTRICIDAD CON SERIES DE TIEMPO

Revista EIA
La alta volatilidad de los precios de la electricidad ha motivado a diseñar a investigadores y académicos modelos que permitan pronosticar la demanda de la misma en el corto, mediano y largo plazo.
Víctor Daniel Gil Vera
doaj  

Durabilidade de um adesivo epóxi e um laminado de CFRP expostos a distintas condições ambientais [PDF]

, 2015
No contexto das estruturas reforçadas, os polímeros reforçados com fibras de carbono (CFRP) são normalmente colados aos elementos a reforçar através de adesivos epóxidos. Nas duas últimas décadas tem sido desenvolvida significativa investigação, dedicada
Correia, Luís Luciano Gouveia, Fernandes, Pedro Miguel Gomes, Sena-Cruz, José, Silva, Patrícia Moreira   +3 more
core  

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source

EFETIVIDADE DA FISIOTERAPIA COM TREINAMENTO SEMI-SUPERVISIONADO DE DUPLA TAREFA NO SISTEMA MOTOR E COGNITIVO EM INDIVÍDUOS COM DOENÇA DE PARKINSON: ESTUDO DE CASOS [PDF]

, 2017
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.O objetivo é analisar a efetividade de um programa fisioterapêutico semi-supervisionado com treinamento de duplas tarefas cognitivas, motoras e cognitivo-motoras durante a ...
Lopes, Carolini Lima
core  

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Diferentes métodos de avaliação do comportamento da ligação de laminados de CFRP ao betão de acordo com a técnica NSM [PDF]

, 2012
O presente trabalho pretende contribuir para o conhecimento da durabilidade da técnica baseada na inserção de laminados de CFRP (Carbon Fiber Reinforced Polymer) no betão de recobrimento (NSM, Near-Surface Mounted).
Barros, Joaquim A. O., Coelho, Mário Rui Freitas, Fernandes, Pedro Miguel Gomes, Sena-Cruz, José, Silva, Patrícia, Xavier, José   +5 more
core  

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Análise de homogeneidade de temperatura mínima mensal para o Estado de São Paulo. [PDF]

, 2017
Neste trabalho, o pacote Climatol-R foi aplicado a 122 séries mensais de temperatura mínima, cobrindo o interior do estado de São Paulo para os anos 1940 até 2012.bitstream/item/144640/1/BolPesq41 ...
ASSAD, E. D., CARVALHO, J. R. P. de, NAKAI, A. M., OLIVEIRA, A. F. de   +3 more
core