Results 21 to 30 of about 136,524 (172)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Surveillance et lutte contre l'épizootie 2013 de fièvre catarrhale ovine de sérotype 1 en Corse [PDF]

, 2013
Le 2 septembre 2013, des signes cliniques évocateurs de fièvre catarrhale ovine (FCO) ont été observés dans deux élevages ovins en Corse. Les analyses du laboratoire national de référence en virologie pour la FCO ont confirmé la présence du sérotype 1 du
Perrin, Jean-Baptiste, Gallois, Mélanie, Breard, Emmanuel, Calavas, Didier, Guis, Hélène, Sailleau, Corinne, Dominguez, Morgane, Hendrikx, Pascal, Clément, Thomas, Viarouge, Cyril, Zientara, Stéphan   +10 more
core  

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Entérite infectieuse du veau à Escherichia coli dans un ranch du Mali [PDF]

, 1981
Au ranch de Madina Diassa (Mali), à partir d'un veau nouveau-né mourant de diarrhée infectieuse, une souche d'Escherichia coli entéropathogène, de sérotype 0111.K 58, est isolée dans divers tissus.
Planchenault, Dominique, Sartirano, E., Bréard, Alain, Tacher, Georges   +3 more
core   +5 more sources

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Infection par le virus Bluetongue sérotype 8 et performances dans les troupeaux bovins laitiers

, 2012
National audienceL’émergence de la fièvre catarrhale ovine, due au virus Bluetongue sérotype 8 (BTV-8) en Europe du Nord en 2006 a causé des pertes économiques en élevage bovin.
Monestiez, Pascal, P., Joly, Alain, Fourichon, Christine, Beaudeau, François, Seegers, Henri, H., Souty, Cécile, Nusinovici, Simon   +6 more
core   +4 more sources

Epidémiologie descriptive de la fièvre catarrhale ovine à sérotype 1 en 2008 en France [PDF]

, 2009
La fièvre catarrhale ovine (FCO) est une maladie virale vectorielle non contagieuse des ruminants. Le virus (Orbivirus, Reoviridae) est transmis par des femelles hématophages de moucheron piqueur du genre Culicoides (Diptera, Ceratopogonidae).
Nouar, Ania
core   +2 more sources

Méningite à Streptococcus pneumoniae sérotype 7A chez un nourrisson immunisé par deux doses du vaccin pneumococcique conjugué 13-valent: à propos d’un cas [PDF]

, 2019
Cause majeure de morbidité et mortalité, les méningites à pneumocoque (PNO) représentent un fléau mondial. Au Maroc, le vaccin conjugué 13-valent contre le pneumocoque (PCV13) a été introduit dans le Programme National de Vaccination en octobre 2010 ...
Khalid Zerouali, Hind El Bayed Sakkali, Fakhreddine Maaloum, Mohamed Bezzari, Kaoutar Ouazzani Touhami, Houria Belabbes, Idrissa Diawara, Makine Ouazzani Touhami   +7 more
core  

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source