Synthesis and Cytotoxic Activity of 1,3-Selenazole-2-Amine Derivatives With Computational ADMET Profiling. [PDF]
ChemistryOpenFour novel 1,3‐selenazole‐2‐amine derivatives were synthesized and evaluated in HT‐29, MCF‐7, and L929 cell lines. Compound 4 showed the highest MCF‐7 cytotoxicity. Compound 3 displayed low L929 toxicity. In silico ADMET predicted favorable pharmacokinetic properties.
Dilek G, Akkoc S.
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Gelatin-Based Head Phantoms: A Practical Guide for Artificial Brain Signal Research. [PDF]
Int J BiomaterBackground The involvement of human subjects in the development of biomedical devices presents both ethical and practical challenges. Electroencephalography (EEG) signals exhibit interindividual variability and are subject to fluctuations induced by movement and emotional states.
Selçuk EN, Çakmak G, Usal MR.
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In Vitro Antioxidant Potential of Various Plant Extracts and Application of the Extracts With the Highest Antioxidant Activity in Ground Beef for Enhancing the Quality and Shelf Life. [PDF]
Food Sci NutrThis study aimed to assess in vitro antioxidant activity of P, AR, CR, CA and L extracts, and then select those with the highest antioxidant activity (P and CA) and evaluate their influence on lipid oxidation, physico‐chemical and microbiological features in cooked ground beef.
Bayındır H, Kılıç B, Yıldız M.
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Prophylactic Effects of Radiofrequency Electromagnetic Field on Pulmonary Ischemia-Reperfusion via HIF-1α/eNOS Pathway and BCL2/BAX Signaling. [PDF]
Pulm CircABSTRACT This study aimed to investigate the vascular effects of a radiofrequency electromagnetic field (RF‐EMF) applied in the lung ischemia and reperfusion (IR) model on the hypoxia‐inducible factor 1 alpha (Hif‐1α)/endothelial nitric oxide synthase (eNOS) pathway and B cell lymphoma 2 (BCL2)/BCL‐2 associated X protein (BAX) signaling.
Akin SE +9 more
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Remifentanil Ameliorates Lipopolysaccharide-Induced Neuroinflammation by Regulating the Phosphatidylinositol 3-Kinase/Serine-Threonine Protein Kinase/Hypoxia-Inducible Factor 1 Alpha Pathway. [PDF]
Pharmacol Res PerspectThe protective mechanisms of REM in neuroinflammation. Damage to the blood–brain barrier is accompanied by increased intercellular junction proteins ZO‐1 and CLDN5 in cortical tissue. At the cellular level, damage induced by LPS activates the PI3K/AKT/HIF‐1α pathway, releasing pro‐inflammatory and pro‐apoptotic substances such as TNF‐α and Cas‐3.
Özcan MS +5 more
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Glutathione Decreases Parkinsonism-Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells. [PDF]
Pharmacol Res PerspectABSTRACT Parkinson's disease (PD) is the most prevalent neurodegenerative disease. Previously, it was believed that aberrant iron metabolism, leading to ferroptosis due to glutathione (GSH) depletion, excessive Ca2+ influx, mitochondrial (mROS), and cytosolic (cROS) free reactive oxygen species in the brain, was a contributing factor to PD. ADP‐ribose (
Güzel E +2 more
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Evaluation of MENAQUINONE-7 and fat-soluble vitamin production by starter cultures during fermentation in dairy products using RPLC method. [PDF]
Food Sci NutrVitamin K2 (menaquinone‐7, MK‐7) levels were measured during the fermentation of various dairy products. Six different fermented milk products were analyzed, including yogurt, kefir, and milk fermented with probiotics. Reverse phase liquid chromatography (RPLC) was used to quantify vitamin contents. The highest MK‐7 content (4.82 μg/100 g) was found in
Altuncu V +4 more
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Effects of using pomegranate peel, beet leaf, and broccoli flower extracts on oxidative stability and physicochemical properties of cooked ground beef during refrigerated storage. [PDF]
Food Sci NutrIt may be concluded that pomegranate peel, beet leaf, and broccoli flower extracts may be utilized by the meat processors to achieve prolonged shelf life and improved quality features. Abstract Plant extracts gained attention in the meat industry for their role in preventing microbial growth and oxidative deterioration.
Şimşek S, Kılıç B.
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Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2021 AmaçBu çalışmada, Subaraknoid Kanama (SAK) sonrasındaserebellar dokuda meydana gelen oksidatif stresüzerinde, uygulanabilecek farklı tedavi modalitelerininetkilerinin değerlendirilmesi amaçlanmıştır.Gereç-ve YöntemKuyruk arterlerinden alınan 0,3 cc ...
Ali Serdar Oğuzoğlu +5 more
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PROSTAT-SPESİFİK MEMBRAN ANTİGEN MENENGİOM TEDAVİSİNDE YER ALABİLİR Mİ?
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2023 AmaçTümör oluşumunda ve ayırıcı tanısında tümör anjiogeneziönemli bir unsur ve değerli bir göstergedir.Menengiomlar vasküleritesi yüksek tümörler olmasınedeni ile bu çalışmada, farklı tedavi protokolleriningeliştirilebilmesi açısından menengiomlarda ...
Ali Serdar Oğuzoğlu +4 more
doaj +1 more source