Results 1 to 10 of about 21 (21)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

MICA Allelic Variation Modulates Secretion and Protein Flexibility, Impacting on NKG2D‐Mediated Immune Responses and Antibody Detection

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Differential secretion mechanisms and predicted structural flexibility are described as additional effects of MICA polymorphism in the immune response. Structural features might explain impaired antibody recognition of certain MICA alleles, supporting that MICA genotyping should be considered in biomarker studies and NKG2D‐based therapeutic development.
Silvia López‐Borrego, Karen Toledo‐Stuardo, Douglas J. Matthies, Marta González‐Matesanz, María Carmen Molina, Mar Valés‐Gómez   +5 more
wiley   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Dynamics of Purification in Cu2O

physica status solidi (b), Volume 263, Issue 3, March 2026.
Rydberg excitons in Cu2O have been shown to be highly efficient in neutralizing and screening charged impurities, which is referred to as purification. In this manuscript, the dynamics of the purification process are investigated under varying probe exciton‐ and plasma density. The transient absorption of Rydberg excitons is analyzed and five different
Binodbihari Panda, Juliane Rütter, Julian Heckötter, Marc Alexander Aßmann   +3 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Monitoring of the Oxidation–Reduction Potential and Its Effects on the Chemical Composition of Grenache, Syrah, and Mourvèdre Wines and Their Blends

Australian Journal of Grape and Wine Research, Volume 2026, Issue 1, 2026.
Oxidation–reduction potential (ORP) is frequently used as an indicator of oxygen exposure during red wine fermentation, but its role as a control variable across grape varieties and blending is not understood. In this study, alcoholic fermentations of Grenache (GR), Syrah (SY), and Mourvèdre (MO) were conducted in quadruplicate under three ORP ...
W. Jordan Wright, Sean Kuster, Biljana Petrova, Jesus Villalobos, James Nelson, Robert E. Coleman, L. Federico Casassa, Leigh Schmidtke   +7 more
wiley   +1 more source

Excited State Assignment and State‐Resolved Photoelectron Circular Dichroism in Chalcogen‐Substituted Fenchones

ChemPhysChem, Volume 26, Issue 23, November 28, 2025.
Fenchone, thiofenchone, and selenofenchone (chalcogenofenchones) are characterized using gas‐phase spectroscopic experiments. The experimentally determined energies of excited states are supported by quantum chemical calculations. Furthermore, near‐ultraviolet femtosecond laser pulses are used to measure the state‐resolved photoelectron circular ...
Sudheendran Vasudevan, Steffen M. Giesen, Simon T. Ranecky, Lutz Marder, Igor Vidanović, Manjinder Kour, Catmarna Küstner‐Wetekam, Nicolas Ladda, Sagnik Das, Tonio Rosen, Vidana Popkova, Han‐gyeol Lee, Denis Kargin, Tim Schäfer, Andreas Hans, Thomas Baumert, Robert Berger, Hendrike Braun, Arno Ehresmann, Guido W. Fuchs, Thomas F. Giesen, Jochen Mikosch, Rudolf Pietschnig, Arne Senftleben   +23 more
wiley   +1 more source

Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches

Advanced Materials, Volume 37, Issue 36, September 11, 2025.
Integration of computational and experimental approaches for deciphering the underlying mechanism of biomolecular condensates and potential biomaterials design (Created in Biorender. Raza, Z. (2025) https://BioRender.com/irgmeqi). Abstract Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be ...
Qiang Zhu, Zahra Raza, Dzung Do‐Ha, Emma De Costa, Pavlina Sasheva, Luke McAlary, Hadi Mahmodi, Warwick P. Bowen, Lezanne Ooi, Irina Kabakova, Haibo Yu   +10 more
wiley   +1 more source

Polyglutamine expansion induced dynamic misfolding of androgen receptor

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Spinal bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion (pQe) in the N‐terminal transactivation domain of the human androgen receptor (AR‐NTD), resulting in a combination of toxic gain‐ and loss‐of‐function mechanisms. The structural basis of these processes has not been resolved due to the disordered nature of the NTD ...
Laurens W. H. J. Heling, Vahid Sheikhhassani, Julian Ng, Morris van Vliet, Alba Jiménez‐Panizo, Andrea Alegre‐Martí, Jaie Woodard, Willeke van Roon‐Mom, Iain J. McEwan, Eva Estébanez‐Perpiñá, Alireza Mashaghi   +10 more
wiley   +1 more source