Results 121 to 130 of about 612,422 (286)

CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. [PDF]

, 2010
INTRODUCTION: Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 gene.
Abraham, Jean E, Baynes, Caroline, Caldas, Carlos, Driver, Kristy E, Dunning, Alison M, Earl, Helena M, Greenberg, David, Ingle, Susan, Kalmyrzaev, Bolot, Luccarini, Craig, Maranian, Mel J, Pharoah, Paul DP, Platte, Radka, Shah, Mitul   +13 more
core   +2 more sources

S-GENOTYPING OF SOME SWEET CHERRY CULTIVARS RELEASED WITHIN BREEDING PROGRAMMES IN THE BALKAN REGION

Journal of Agricultural, Food and Environmental Sciences, 2018
Sweet cherry cultivars generally exhibit S-ribonuclease (S-RNase)-based gametophytic selfincompatibility and require pollination with pollen of compatible genotypes, which are indispensable to stable fruit production. Therefore, the determination of S-genotype provides relevant information for sweet cherry breeders and growers.
Marić, Slađana, Radičević, Sanja, Sirbu, Sorina, Zhivondov, Argir, Cerović, Radosav, Milošević, Nebojša   +5 more
openaire   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

ORGANIC POULTRY PRODUCTION SYSTEM AND MEAT CHARACTERISTICS [PDF]

, 2005
The effect of the organic poultry production system on some qualitative characteristics of the meat is reported. The effect is mainly due to the greater age and physical activity of animals but it is largely modulated by the farming protocols used e.i ...
CASTELLINI, prof C
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member,GSTM2 [PDF]

, 2013
The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1 null), leading to a lack of corresponding enzymatic activity.
A Rossini, C Carlsten, D Konig-Greger, DA Bell, DL White, E Zintzaras, EC Kenine, FD Vogl, HD Hosgood 3rd, HR Frydoonfar, J Seidegård, JC Mak, JW Sull, L Gamet-Payrastre, L Varela-Lema, LR Bailey, M Traka, MJ Roth, P Board, P Ghosh, R Syed, RA McLellan, RC Strange, RC Strange, S Gronau, S Mishra, S Pemble, SC Cotton, SM Bhosle, SY Park, TD Schmittgen, WL Zhuo, WR Pearson, Z Ye   +33 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Severe fever with thrombocytopenia syndrome virus was found in Northern Jiangxi Province, China

Frontiers in Microbiology
IntroductionSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in China in 2009. SFTS monitoring has been carried out since 2010 in mainland China.
Haijun Hu, Ying He, Fei Chen, Zhanbin Liu, Wei Wang, Shu Yang, Ke Qian, Zhuan Zhan, Yangping Guo, Hui Li, Weiqing Zheng, Weiqing Zheng   +11 more
doaj   +1 more source

Prevalence of α-1-Antitrypsin gene mutations in Saudi Arabia

The Saudi Journal of Gastroenterology, 2011
Background/Aim: α-1 antitrypsin (AAT) deficiency results from mutations of the protease inhibitor (PI). The AAT gene is mapped on chromosome 14 and has been associated with chronic liver disease and chronic obstructive pulmonary disease (COPD). Objective:
Badr Aljarallah, Ahmed Ali, Moataz Dowaidar, Ahmad Settin   +3 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source