Results 71 to 80 of about 612,422 (286)

Transmission dynamics of methicillin-resistant Staphylococcus aureus in pigs [PDF]

open access: yes, 2013
From the mid-2000s on, numerous studies have shown that methicillin-resistant Staphylococcus aureus (MRSA), renowned as human pathogen, has a reservoir in pigs and other livestock.
Argudin, M Angeles   +5 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Quantifying yeast colony morphologies with feature engineering from time-lapse photography

open access: yesScientific Data, 2022
Measurement(s) Yeast colony morphology Technology Type(s) Time-lapse photographs Factor Type(s) Genotype Sample Characteristic - Organism Saccharomyces ...
Andy Goldschmidt   +5 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Incompatible (S-) genotypes of sweet cherry cultivars (Prunus avium L.)

open access: yesScientia Horticulturae, 2012
Sweet cherries are generally self-incompatible, caused by a gametophytic self-incompatibility system. Two genetic factors (S-alleles) determine the fertility of sweet cherry genotypes. Dependent on the S-allele constitution of the cultivars, cross-incompatibility groups of sweet cherry cultivars exist.
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

No association of GSTM1 null polymorphism with endometriosis in women from central and southern Iran [PDF]

open access: yesIranian Journal of Reproductive Medicine, 2012
Background: Endometriosis is one of the most common gynecologic disorders. It is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis.
Razieh Dehghani Firouzabadi   +4 more
doaj  

Hepatitis C virus resistance to the new direct-acting antivirals [PDF]

open access: yes, 2016
Introduction: The treatment of hepatitis C virus (HCV) infection has dramatically improved in recent years with the widespread use of interferon-free combination regimens.
Esposito, Isabella   +2 more
core   +1 more source

The calculation and interpretation of S-genotype segregation in complex incompatibility systems [PDF]

open access: yesHereditas, 2009
To facilitate the investigation of complex incompatibility systems, formulas and methods for the calculation of numbers and configurations of S-genotypes among offspring are presented, and the significance of one-way incompatibilities is expounded.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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