Results 201 to 210 of about 67,130 (231)

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies. [PDF]

Comput Struct Biotechnol J
Weber P, Arnesdotter E, Attar N, Friedrichs S, Seitz C, Chowdhury RR, Koch K, Buerki-Thurnherr T, Brugger B, Wick P, Morikka J, Serra A, Capini L, Greco D, Lacconi V, Marchese AS, Campagnolo L, Exner TE, Brajnik M, Brun É, Lynch I, Zouraris D, Mintis D, Tsoumanis A, Afantitis A, Melagraki G, Minadakis V, Papakyriakopoulou P, Tsiros P, Thépaut E, Sarimveis H, Majó M, Hischier R, Virmani I, Paparella M, Kavaliauskiene S, Sayyari A, Fontaine R, Müller MHB, Lee E, Gerelkhuu Z, Yoon TH, Turan-Sorhun D, Neuhaus W, Serchi T.   +44 more
europepmc   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

The effects of PRRS on the environmental impact of pig production: a life cycle assessment study. [PDF]

Front Vet Sci
Thoma GJ, Galina Pantoja L, Linhares DCL, Serafini Poeta Silva AP, Case L, Knap PW.   +5 more
europepmc   +1 more source

European Identity in Youth: Longitudinal Dynamics and the Role of School Experiences

Journal of Adolescence, EarlyView.
ABSTRACT Introduction For young people in Europe, European identity can serve as an important source of solidarity and belonging, especially in times of growing societal polarization. This study investigates European identity development during adolescence with two aims: (1) to identify European identity profiles, their associations with civic and ...
Astrid Körner, Katharina Eckstein, Anna‐Maria Mayer, Philipp Jugert, Peter Noack   +4 more
wiley   +1 more source

Modeling approaches for estimating the effects of risk factors using longitudinal lifecourse exposure data in dementia research. [PDF]

Alzheimers Dement
Nichols E, Bindas A, Atshan S, Chang H, Chiang YY, Claus Henn B, Hayes-Larson E, Keller KP, Kezios KL, Shih RA, Szpiro AA, Weiss J, Adar SD, Knapp DM, Lee J, Weuve J.   +15 more
europepmc   +1 more source

Characterising the classes of children and young people with mental health concerns based on reported service contact

JCPP Advances, EarlyView.
Abstract Background Exploring the similarities and differences of mental health‐based service contact behaviours for children and young people (CYP) and associated characteristics will allow for distinct analysis of identified groups, and inform both current support pathways alongside more focussed targeted intervention strategies.
Frances Mathews, Chris Playford, Obioha C. Ukoumunne, Tamsin J. Ford, Tamsin Newlove‐Delgado   +4 more
wiley   +1 more source

Integration of safety and sustainability criteria into early design stages of battery cell manufacturing machinery. [PDF]

Sci Rep
Cerrillo C, Mendoza G, Ormazabal G, Popok V, Oetting H, Konersmann B, Tedeschi Gallo A, Lavigne Philippot M.   +7 more
europepmc   +1 more source