Results 181 to 190 of about 432,483 (291)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Tag-mediated effect on the dynamics of social influence. [PDF]

PLoS One
He X, Cheng G, Lu J.
europepmc   +1 more source

Measurement of the tt Production Cross Section in pp Collisions at √ s=1.96TeV using Soft Electron b- Tag-ging

, 2010
T. Aaltonen, P. Barria
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

In Vitro Refolding of Vault-like Protein Nanocapsules with a Novel Scaffolding Mechanism. [PDF]

Int J Mol Sci
Breen G, Gonzales M, Yeh G, Delyon T, McNeill C, Lenci A, Thong S, Burton R.   +7 more
europepmc   +1 more source

Measurement of charged hadron production in $Z$-tagged jets in proton-proton collisions at $\sqrt{s}=8$ TeV

LHCb Collaboration
openalex   +1 more source

Mesoporous Ionically Tagged Cross-Linked Poly(vinyl imidazole)s as Novel and Reusable Catalysts for the Preparation of N-Heterocycle Spiropyrans

, 2019
Hassan Sepehrmansourie, Mahmoud Zarei, Reza Taghavi, Mohammad Ali Zolfigol   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Controlling Intramolecular Rotation with Five-Membered Heterocycles Facilitates the Design of Highly Cell-Permeable Xanthene-Based Fluorogenic Probes. [PDF]

J Am Chem Soc
Reja SI, Hori Y, Takeda Y, Nishiura M, Minoshima M, Kikuchi K.   +5 more
europepmc   +1 more source

MEASUREMENT OF THE BRANCHING FRACTIONS FOR INCLUSIVE B{sup -} AND {bar B}{sup 0} DECAYS TO FLAVOR-TAGGED D, D{sub S} AND LAMBDA{sub C}

, 2004
B. Aubert
openalex   +2 more sources