Results 271 to 280 of about 432,483 (291)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A surface acoustic wave tag utilizing a multilayer structure of SiO₂/Pt/128°YX-LiNbO₃ for operation at 600 °C. [PDF]

Microsyst Nanoeng
Tang Z, Shi R, Guo D, Luo C, Li H, Han T.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins. [PDF]

J Pept Sci
Møller DN, Kofoed C, Thygesen MB, Jensen KJ.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experimental Validation of Modeling Approaches Describing the Crystallization of Pure Triacylglycerides and Their Mixtures: A Review. [PDF]

Compr Rev Food Sci Food Saf
Lessona M, Cros A, Sagalowicz L, Harshe Y, Buffo A, Simone E.   +5 more
europepmc   +1 more source

Gross lesions on S. siderea colonies Examples of S. siderea lesions on colonies tagged in Fort Lauderdale (A and B) and Florida Keys (C and D).

Greta Smith Aeby (4598455), Yasunari Kiryu (11405537), Jan Landsberg (22001626), Blake Ushijima (131681), Scott Jones (65289), L. Jay Houk (15192520), Joseph Kuehl (11439271), Valerie J. Paul (307783)   +7 more
openalex   +1 more source

A Histone Code Functionally Linked to Replicative Senescence. [PDF]

Aging Cell
Suter T, Friedman MJ, Tazearslan C, Gamliel A, Merkurjev D, Ohgi K, Zhou Z, G Rosenfeld M, Suh Y.   +8 more
europepmc   +1 more source

A Novel Unadjuvanted Subunit Respiratory Syncytial Virus Prefusion F Vaccine Induces Potent and Differentiated Functional Immune Responses Compared to AS01-Adjuvanted Arexvy in Older Adults. [PDF]

Open Forum Infect Dis
Richmond P, Kwan TTL, Rook C, Sun A, Tan W, Jackson N, Ambrosino D, Siber G, Costa-Clemens SA, Clemens R, Burdin N, Liang JG.   +11 more
europepmc   +1 more source

Representative photos of tagged S. siderea with lesions at Fort Lauderdale.

Greta Smith Aeby (4598455), Yasunari Kiryu (11405537), Jan Landsberg (22001626), Blake Ushijima (131681), Scott Jones (65289), L. Jay Houk (15192520), Joseph Kuehl (11439271), Valerie J. Paul (307783)   +7 more
openalex   +1 more source