Results 111 to 120 of about 21,517,583 (302)

Innate host defense lysozyme may help control Staphylococcus aureus in atopic dermatitis

Microbiology Spectrum
Atopic dermatitis (AD) is a chronic pruritic skin condition characterized by lesions associated with colonization and infection by Staphylococcus aureus. There is growing evidence that S.
Patrick M. Schlievert, Samuel H. Kilgore, Evgeny Berdyshev, Michael Nodzenski, Gloria David, Takeshi Yoshida, Lisa A. Beck, Donald Y. M. Leung   +7 more
doaj   +1 more source

S. aureus Toxins Join the DARC Side [PDF]

Cell Host & Microbe, 2015
Staphylococcus aureus, like other bacterial pathogens, scavenges host iron for growth through incompletely understood mechanisms. In this issue of Cell Host & Microbe, Spaan et al. (2015) demonstrate that two Staphylococcus aureus leukotoxins, HlgAB and LukED, target the Duffy antigen receptor for chemokines on erythrocytes, resulting in lysis and iron
openaire   +2 more sources

Antibiotic Resistance Pattern of Isolated Strains of Staphylococcus Aureus from Personnel Nasal Specimens in Meshgin Shahr Valiasr Hospita [PDF]

Background & Objectives: Staphylococcus aureus is known as an important pathogen causing a variety of bacterial infections. Treatment of this bacterium with antibiotics has led to antibiotic-resistancy, especially against methicillin (MRSA) and more ...
کریم وند, نسیم, نيك بخت, مجتبي, حسن نژاد, سيامك, فرجي, فاطمه, رضازاده, بابك, قرباني, فياض, نقی زاده باقی, عباس   +6 more
core  

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Staphylococcus aureus shifts towards commensalism in response to Corynebacterium species

Frontiers in Microbiology, 2016
Staphylococcus aureus–human interactions result in a continuum of outcomes from commensalism to pathogenesis. S. aureus is a clinically important pathogen that asymptomatically colonizes ~25% of humans as a member of the nostril and skin microbiota ...
Matthew M Ramsey, Matthew M Ramsey, Marcelo O Freire, Marcelo O Freire, Rebecca A Gabrilska, Kendra P Rumbaugh, Katherine P Lemon, Katherine P Lemon   +7 more
doaj   +1 more source

The ups and downs of S. aureus nasal carriage

Mathematical Medicine and Biology: A Journal of the IMA, 2018
AbstractStaphylococcus aureus infections are a growing concern worldwide due to the increasing number of strains that exhibit antibiotic resistance. Recent studies have indicated that some percentage of people carry the bacteria in the nasal cavity and therefore are at a higher risk of subsequent, and more serious, infections in other parts of the body.
Angela M, Jarrett, Nicholas G, Cogan
openaire   +2 more sources

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus [PDF]

, 2011
Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with ...
Rahman, Khondaker; id_orcid, Thurston, DE, Taylor, PW, Feuerbaum, EA, Helena Rosado, David E. Thurston, Rahman, KM, Peter W. Taylor, Rosado, H, Hinds, J, Khondaker M. Rahman, Jason Hinds, Eva-Anne Feuerbaum   +12 more
core   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Staphylococcus saprophyticus prevents skin damage by inhibiting Staphylococcus aureus quorum sensing

Scientific Reports
Coagulase-negative staphylococci are prominent skin commensals that play a crucial role in maintaining skin homeostasis and eliminating pathogens. Coagulase-negative staphylococci, such as Staphylococcus caprae, S. hominis, S. simulans, and S.
Liuying Song, Xiaobao Bai, Sushma Halekote Rudramurthy, Tauqeer Alam, Michael Otto, Masanori Matsumoto   +5 more
doaj   +1 more source