Results 131 to 140 of about 208,447 (213)

Characteristics, therapeutic pathway and the economic burden of patients with drug‐resistant epilepsy: A real‐world analysis following the introduction of cenobamate in Italy

Epilepsia, EarlyView.
Abstract Objectives Drug‐resistant epilepsy (DRE) remains a major clinical challenge, affecting approximately one‐third of patients with epilepsy. Cenobamate, a novel antiseizure medication (ASM) approved in Italy in 2022, has shown promise in clinical trials. However, real‐world data on its use, especially economic evaluations, remain limited.
Valentina Perrone, Chiara Veronesi, Maria Cappuccilli, Margherita Andretta, Marcello Bacca, Antonietta Barbieri, Fausto Bartolini, Alessandro Brega, Maria Rosaria Cillo, Francesco Colasuonno, Stefania Dell'Orco, Fulvio Ferrante, Stefano Grego, Antonella Lavalle, Daniela Mancini, Maurizio Pastorello, Romina Pagliaro, Cataldo Procacci, Camilla Scandolara, Patrizia Schiavone, Loredana Ubertazzo, Paola Valpondi, Adriano Vercellone, Alberto Zucchi, Maria Ciappetta, Domenico Lucatelli, Andrea Cinti Luciani, Luca Degli Esposti   +27 more
wiley   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

Leadless Versus Transvenous Dual‐Chamber Pacemakers: Real‐World Evidence From AVEIR DR Coverage With Evidence Development Study

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background AVEIR DR, an industry‐first dual‐chamber leadless pacemaker (LP), provides continuous atrioventricular synchrony through implant‐to‐implant (i2i) communication between atrial and ventricular LP devices. It is important to evaluate the early real‐world comparative safety of AVEIR DR LP.
Monica Lo, Anish K. Amin, Marcin Kowalski, Anne Kroman, Dilip Mathew, Valay Parikh, Stanislav Weiner, Jennifer M. Joseph, Leonard Ganz, Mohammed Mortada, AVEIR DR Study Group/Consortium   +10 more
wiley   +1 more source

Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Functional impairment (FI) is a key criterion for diagnosing dementia. However, subtle functional changes may occur during preclinical and prodromal phases but may not be accurately characterized. Furthermore, research linking FI to Alzheimer disease (AD) biofluid biomarkers is limited.
Maryam Ghahremani, Eric E. Smith, Zahinoor Ismail   +2 more
wiley   +1 more source

Multidimensional associations of physical performance, balance, wellness and daily activities with frailty in older adults with coexisting frailty and diabetes

Journal of Clinical Nursing, EarlyView.
Abstract Background The coexistence of frailty and type 2 diabetes mellitus in the older population heightens the risk of adverse events. However, research on functional and wellness factors associated with frailty in this population is limited. Purpose To investigate the associations of physical performance, functional dependency, physical activity ...
Juan Corral‐Pérez, Alba Mier, María Ángeles Vázquez‐Sánchez, María Naranjo‐Márquez, Jesus Gustavo Ponce‐Gonzalez, Cristina Casals   +5 more
wiley   +1 more source

Machine learning-based prediction of atrial fibrillation in patients with atrial high-rate episodes. [PDF]

Eur J Clin Invest
Abstract Background Given the modest performance of available predictive models in estimating the risk of atrial fibrillation (AF) in patients with atrial high‐rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs), this study explores the potential use of machine learning (ML) algorithms in this context. Purpose To assess the
Askarinejad A, Bucci T, Asgharzadeh N, Amirjam Z, Tartaglia E, Rossi M, Chen Y, Zheng Y, Lip GYH, Haghjoo M.   +9 more
europepmc   +2 more sources

Revised phylogeny of the Inula complex group (Asteraceae: Inuleae) with a recircumscription of Carpesium and establishment of a new genus Cladocarpesium

Journal of Systematics and Evolution, EarlyView.
Cladocarpesium T. Deng & Qun Liu, gen. nov. (Separated from Carpesium) is established with Cladocarpesium abrotanoides (L.) T. Deng & Qun Liu designated as the type species. The new genus is morphologically distinct from Carpesium s.str. by its sympodial growth form (typically producing three branches), sessile capitula, and three‐seriate phyllaries ...
Qun Liu, Nan Lin, Dai‐Gui Zhang, Xian‐Han Huang, Yan‐Bo Li, Ying‐Ying Zheng, Umida Tojiboeva, Jian‐Wen Zhang, Tao Deng   +8 more
wiley   +1 more source

– En kvalitativ intervjustudie med åtta förskollärare om inkluderande strategier i förskolan. [PDF]

Det har rapporterats en ökning bland diagnostiserade barn med autism i Sverige. Förskolan ska ta hänsyn till alla barn oavsett funktionsnedsättning.
Gimfalk, Sofia, Sultan, Sandra
core  

Eye Movements, Item Modality, and Multimodal Second Language Vocabulary Learning: Processing and Outcomes

Language Learning, EarlyView.
Abstract This study examined second language vocabulary processing and learning in reading only (RO) versus reading while listening (RWL). 119 English learners read or read‐while‐listening to a story embedded with 25 pseudowords, 10 times each, and had their eye movements tracked.
Jonathan Malone, Bronson Hui, Nick Pandža, Tetiana Tytko   +3 more
wiley   +1 more source

Patient and System Barriers to Early Diagnosis of Oral Cancer in the UK

Oral Diseases, EarlyView.
ABSTRACT Objective Oral cancer poses a significant public health challenge worldwide, especially in the UK, where delayed diagnosis negatively impacts patient outcomes and survival rates. This study aims to systematically review and synthesise evidence on patient and system barriers to early diagnosis of oral cancer within the UK context.
Emmanuel Kwateng Drokow, Michael Drinnan, Cecilia Amponsem‐Boateng, Fatemeh Vida Zohoori, Janet A. Wilson, Kamini Shah, Francisca Arboh   +6 more
wiley   +1 more source