Results 11 to 20 of about 365,074 (146)

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

bioRxiv, 2020
SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission.
Lizhou Zhang, C. B. Jackson, H. Mou, Amrita Ojha, E. Rangarajan, T. Izard, M. Farzan, H. Choe   +7 more
semanticscholar   +1 more source

Pharmacophore-Based Virtual Screening, Quantum Mechanics Calculations, and Molecular Dynamics Simulation Approaches Identified Potential Natural Antiviral Drug Candidates against MERS-CoV S1-NTD

Molecules, 2021
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious zoonotic virus first reported into the human population in September 2012 on the Arabian Peninsula. The virus causes severe and often lethal respiratory illness in humans with
Thamer Bouback, Sushil Pokhrel, Abdulaziz Albeshri, Amal Mohammed Aljohani, A. Samad, Rahat Alam, Md Saddam Hossen, Khalid Al-Ghamdi, Md. Enamul Kabir Talukder, Foysal Ahammad, I. Qadri, J. Simal-Gándara   +11 more
semanticscholar   +1 more source

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

Nature Neuroscience, 2020
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein.
E. Rhea, A. Logsdon, Hansen M. Kim, Lindsey M. Williams, M. Reed, Kristen K. Baumann, Sarah Holden, J. Raber, W. Banks, M. Erickson   +9 more
semanticscholar   +1 more source

The Companion effect between Salicylic acid and Glutamine on the growth and yield of water-stressed cucumber (Cucumis sativus L. )

IOP Conference Series: Earth and Environment, 2019
Trial was conducted in greenhouse of the Department of biology / College of Science/University of Diyala during autumn season 2016. The study included two levels of water stress ( S1/Irrigation for 14 minutes and S2 / Irrigation for 7 minutes/7 ml of ...
Z. H. Hamid, R. Mansoor
semanticscholar   +1 more source

Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone

Inflammation, 2021
An understanding of the pathological inflammatory mechanisms involved in SARS-CoV-2 virus infection is necessary in order to discover new molecular pharmacological targets for SARS-CoV-2 cytokine storm.
O. Olajide, Victoria U. Iwuanyanwu, Izabela Lepiarz-Raba, A. Al-hindawi   +3 more
semanticscholar   +1 more source

In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients

Infectious Disease and Therapy, 2021
Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 assays in oligo-/asymptomatic individuals from a population-based cohort. In
R. Rubio-Acero, N. Castelletti, V. Fingerle, Laura Olbrich, A. Bakuli, R. Wölfel, P. Girl, K. Müller, S. Jochum, M. Strobl, M. Hoelscher, A. Wieser, Emad Jared Valeria Maximilian Marieke Marc Jessica Rebe Alamoudi Anderson Baldassare Baumann Behlen Becker, Emad Alamoudi, Jared Anderson, Valeria Baldassare, M. Baumann, Marieke Behlen, M. Becker, J. Beyerl, Rebecca Böhnlein, I. Brand, Anna Brauer, Vera Britz, J. Bruger, Friedrich Caroli, L. Contento, Alina Czwienzek, F. Déak, E. Dech, Laura Dech, Maximillian N. Diefenbach, Jana Diekmannshemke, Anna Do, G. Dobler, U. Eberle, J. Durner, Judith Eckstein, T. Eser, P. Falk, Jonathan Frese, Stefanie Fischer, Felix Forster, T. Frahnow, G. Fröschl, C. Fuchs, Mercè Garí, Marius Gasser, S. Gauder, O. Geisenberger, C. Geldmacher, Kristina Gillig, Elias Golschan, Vitus Grauvogl, J. M. Guggenbuehl Noller, Celina Halfmann, Tim Haselwarter, J. Hasenauer, Arlett Heiber, M. Herrmann, Stefan Hillmann, Christian Hinske, Janna Hoefflin, Tim Hofberger, Michael Höfinger, L. Hoffmann, Sacha Horn, K. Huber, C. Janke, Ursula Kappl, Charlotte Kiani, Isabel Klugherz, Norah Kreider, I. Kroidl, A. Kroidl, Magdalena Lang, Clemens Lang, Silvan Lange, E. Lapteva, M. Laxy, R. Le Gleut, R. Leidl, Felix Lindner, Alexander Maczka, A. Markgraf, Paula Matcau, R. Mayrhofer, Anna-Maria Mekota, Hannah Müller, Dafni Metaxa, Leonie Pattard, I. Paunović, C. Pleimelding, M. Pletschette, M. Pritsch, S. Prückner, Kerstin Puchinger, Konstantin Pusl, Peter Pütz, K. Radon, E. Raimúndez, Julius Raschka, Jakob Reich, F. Riess, Camila Rothe, E. Saathoff, N. Schäfer, Yannik Schälte, Paul Schandelmaier, L. Schneider, S. Schultz, M. Schunk, L. Schwettmann, H. Seibold, Peter Sothmann, P. Stapor, Jeni Tang, F. Theis, Verena Thiel, S. Thiesbrummel, E. Thumser, Niklas Thur, Julian Ullrich, J. Waibel, Claudia Wallrauch, S. Winter, Julia Wolff, Pia Wullinger, T. Würfel, Patrick Wustrow, Houda Yaqine, S. Zange, E. Zeggini, Thomas Zimmermann, Lea Zuche   +134 more
semanticscholar   +1 more source

SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia

Molecular Neurobiology, 2021
In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence suggests that some neurological symptoms are associated with the disease caused by this coronavirus. In this study, we investigated the effects of the SARS‐CoV‐2 spike
O. Olajide, Victoria U. Iwuanyanwu, O. D. Adegbola, A. Al-hindawi   +3 more
semanticscholar   +1 more source

A bivalent recombinant vaccine targeting the S1 protein induces neutralizing antibodies against both SARS‐CoV‐2 variants and wild‐type of the virus

MedComm, 2021
The emerging variants of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) in pandemic call for the urgent development of universal corona virus disease 2019 (COVID‐19) vaccines which could be effective for both wild‐type SARS‐CoV‐2 and mutant
Cai He, Jingyun Yang, Xuemei He, Weiqi Hong, H. Lei, Zimin Chen, G. Shen, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, G. Lu, Xiawei Wei   +13 more
semanticscholar   +1 more source

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

Emerging Microbes and Infections, 2020
The emergence of SARS-CoV-2 has led to the current global coronavirus pandemic and more than one million infections since December 2019. The exact origin of SARS-CoV-2 remains elusive, but the presence of a distinct motif in the S1/S2 junction region ...
S. Lau, Pui Wang, B. Mok, A. J. Zhang, Hin Chu, A. Lee, Shaofeng Deng, Pin Chen, Kwok-Hung Chan, Wenjun Song, Zhiwei Chen, K. To, J. Chan, K. Yuen, Honglin Chen   +14 more
semanticscholar   +1 more source

Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses

Journal of Neuroimmune Pharmacology, 2021
Spike S1 of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) on host cells to enter the cell and initiate COVID-19.
Ramesh K Paidi, M. Jana, S. Raha, M. McKay, M. Sheinin, Rama K. Mishra, K. Pahan   +6 more
semanticscholar   +1 more source