Results 201 to 210 of about 2,662,698 (247)

Distribution of bladder afferent activity across the sacral roots in sheep shows marked individual variation: implications for neuroprosthesis design. [PDF]

Front Neurosci
Prager J, Petrou M, Leonhardt M, Jabban L, Granger N, Taylor J, Donaldson N, Metcalfe B.   +7 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spatial and multi-omic profiling reveals pericyte-derived CCL19 as a key prognostic factor in CNS lymphoma. [PDF]

Hemasphere
Kuehn JC, Miarka L, Sankowski R, Mutter J, Neidert NN, Grabis E, Zhang J, Klingler C, Hummel F, Ranganathan L, Bleul S, Lauer EM, Heiland DH, Müller K, Reinhardt HC, Dietrich S, Illerhaus G, von Baumgarten L, Alig S, Diehn M, Sajonz BEA, Beck J, Coenen VA, Prinz M, Schorb E, Alizadeh AA, Duyster J, Reinacher P, Scherer F.   +28 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Combined Metabolome and Transcriptome Analysis of Floral Organ Development in <i>Magnolia cavaleriei</i> var. <i>platypetala</i> 'Tanchun'. [PDF]

Plants (Basel)
Hu Y, Zhang Z, Yong Y, Zhang M, Hu X, Lei W, Zhang D.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Sacral Dysmorphism as an Independent Risk Factor for Cortical Breach During Percutaneous S1 Iliosacral Screw Fixation. [PDF]

J Clin Med
Aktan C, Ergün M, Ünal M, Kahvecioğlu N, Hasoğlan C, Katı YA, Yüksel HY.   +6 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Examining the Role of Pre-Operative Retrolisthesis in Single-Level Lumbar Fusion: Impact on Reoperation Rates. [PDF]

J Clin Med
Patel HA, Suresh RI, Patel S, Lindley AK, Yang E, Kidd G, Honig E, Curto R, Zareef U, Prakash H, Sahai A, Alasadi H, Padovano A, Bivona LJ, Cavanaugh D, Koh EY, Ludwig SC, Jauregui JJ.   +17 more
europepmc   +1 more source