Results 241 to 250 of about 5,471,854 (277)

Multilevel congenital lumbar facet joint aplasia presenting with L5-S1 spondylolisthesis in a patient with connective tissue disease. [PDF]

Surg Neurol Int
Lam VH, Lozano CS, Kassay AD, He Y, Ginsberg HJ.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Electronic and Inertial Effects of Methylation on Excited-State Hydrogen Transfer. [PDF]

J Phys Chem A
Chakraborty P, Couto RC, List NH.
europepmc   +1 more source

Bertolotti joint-related cyst: illustrative case. [PDF]

J Neurosurg Case Lessons
Chow WD, Spinner RJ, Amrami KK, Elder BD, Steinmetz MP.   +4 more
europepmc   +1 more source

Oligomeric lactic acid nanoplastics induce intrauterine growth restriction in mice by disrupting GATA2-mediated placental vascular development. [PDF]

PLoS Biol
Lv J, Wang M, Shi C, Wang Y, Zhang Y, Gao C, Bi TQ, Yang J, Xu Y, Wang Q, Wang H, Xu DX, Fang M, Huang Y.   +13 more
europepmc   +1 more source