Results 261 to 270 of about 1,793,616 (299)
Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer 
 Molecular Oncology, Volume 19, Issue 10, Page 2978-2988, October 2025.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 morewiley    +1 more source
Molecular Oncology, Volume 19, Issue 10, Page 2978-2988, October 2025.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 morewiley    +1 more sourceQuality of Life of Families Who Have Children With Cornelia de Lange Syndrome in Brazil: Opportunities for Improvement 
 American Journal of Medical Genetics Part A, Volume 197, Issue 10, October 2025.ABSTRACT
This exploratory cross‐sectional study aimed to estimate the family quality of life (FQoL) among 70 Brazilian families with children with Cornelia de Lange syndrome (CdLS). Data were collected using sociodemographic and clinical data forms, the Barthel index for activities of daily living, and the Beach Center FQoL Scale, a 5‐point Likert tool Aline Apis, Beatriz Carvalho Nunes, Thainá Vilella, Rafaela Catelan Martins Pereira, Rui Fernando Pilotto, Lucimar Retto da Silva de Avó, Maria Isabel Melaragno, Carla Maria Ramos Germano, Débora Gusmão Melo   +8 morewiley    +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 10, October 2025.ABSTRACT
This exploratory cross‐sectional study aimed to estimate the family quality of life (FQoL) among 70 Brazilian families with children with Cornelia de Lange syndrome (CdLS). Data were collected using sociodemographic and clinical data forms, the Barthel index for activities of daily living, and the Beach Center FQoL Scale, a 5‐point Likert tool Aline Apis, Beatriz Carvalho Nunes, Thainá Vilella, Rafaela Catelan Martins Pereira, Rui Fernando Pilotto, Lucimar Retto da Silva de Avó, Maria Isabel Melaragno, Carla Maria Ramos Germano, Débora Gusmão Melo   +8 morewiley    +1 more sourceNeopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild 
 American Journal of Primatology, Volume 87, Issue 10, October 2025.Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...Verena Behringer, Caroline Deimelwiley    +1 more source
American Journal of Primatology, Volume 87, Issue 10, October 2025.Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...Verena Behringer, Caroline Deimelwiley    +1 more sourceRelação da sensibilidade à feniltiocarbamida (PTC) e o estado nutricional dos pacientes atendidos em um centro de saúde de BrasÃlia - DF 
 , 2007 Morais, Jeovana Rezende Silva, Silva, Juliana Rezende Melo da, Conte, Renata Marques, Grinol, Maria de Nazaré Klautau Guimarães, Raso, Vagner   +4 moreopenaire    +1 more source
, 2007 Morais, Jeovana Rezende Silva, Silva, Juliana Rezende Melo da, Conte, Renata Marques, Grinol, Maria de Nazaré Klautau Guimarães, Raso, Vagner   +4 moreopenaire    +1 more sourceCross‐country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia 
 Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract INTRODUCTION
We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.Liset de Boer, Lize C. Jiskoot, Harro Seelaar, John C. van Swieten, Agustin Ibanez, Marcelo Maito, Sol Fittipaldi, Julie F. H. De Houwer, Tine Swartenbroekx, Pam A. Boesjes, Rhian S. Convery, Eve Ferry‐Bolder, Phoebe Foster, Arabella Bouzigues, Lucy Chisman‐Russell, Esther van den Berg, Janne Papma, Sanne Franzen, Renelle Bourdage, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Elizabeth Finger, Robert Laforce, Caroline Graff, Alexander Gerhard, Raquel Sanchez‐Valle, Alexandre Mendonça, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Thibaud Lebouvier, Benedetta Nacmias, Markus Otto, Christopher R. Butler, Isabel Santana, Maxime Bertoux, M. Carmela Tartaglia, Jonathan D. Rohrer, Jackie M. Poos, the GENFI Consortium   +45 morewiley    +1 more source
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract INTRODUCTION
We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.Liset de Boer, Lize C. Jiskoot, Harro Seelaar, John C. van Swieten, Agustin Ibanez, Marcelo Maito, Sol Fittipaldi, Julie F. H. De Houwer, Tine Swartenbroekx, Pam A. Boesjes, Rhian S. Convery, Eve Ferry‐Bolder, Phoebe Foster, Arabella Bouzigues, Lucy Chisman‐Russell, Esther van den Berg, Janne Papma, Sanne Franzen, Renelle Bourdage, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Elizabeth Finger, Robert Laforce, Caroline Graff, Alexander Gerhard, Raquel Sanchez‐Valle, Alexandre Mendonça, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Thibaud Lebouvier, Benedetta Nacmias, Markus Otto, Christopher R. Butler, Isabel Santana, Maxime Bertoux, M. Carmela Tartaglia, Jonathan D. Rohrer, Jackie M. Poos, the GENFI Consortium   +45 morewiley    +1 more sourcePopulation Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity 
 Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 841-852, October 2025.Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...Patrick O. Hanafin, Ramya Mahadevan, Gauri G. Rao, Alexandre P. Zavascki, Ana Maria Sandri, Andrea Kwa, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P.Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Anthony W. Purcell, Roger L. Nation, Jason M. Pogue, Jian Li, Keith S. Kaye   +19 morewiley    +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 841-852, October 2025.Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...Patrick O. Hanafin, Ramya Mahadevan, Gauri G. Rao, Alexandre P. Zavascki, Ana Maria Sandri, Andrea Kwa, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P.Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Anthony W. Purcell, Roger L. Nation, Jason M. Pogue, Jian Li, Keith S. Kaye   +19 morewiley    +1 more sourceNanostructured Biosensor Based on Multiwalled Carbon Nanotubes and Antimicrobial Peptide Temporin‐PTA for Bacterial Detection 
 Electroanalysis, Volume 37, Issue 10, October 2025.A nanostructured electrochemical biosensor was developed by assembling MWCNTs with the antimicrobial peptide Temporin‐PTA. The platform enables rapid bacterial detection within 5 min, differentiates Gram‐negative from Gram‐positive pathogens, and achieves a low detection limit of 10 CFU/mL.Antônio Oscar Gomes Filho, Alberto Galdino da Silva Júnior, Reginaldo G. Lima‐Neto, Ludovico Migliolo, Maria Danielly Lima de Oliveira, César Augusto Souza de Andrade   +5 morewiley    +1 more source
Electroanalysis, Volume 37, Issue 10, October 2025.A nanostructured electrochemical biosensor was developed by assembling MWCNTs with the antimicrobial peptide Temporin‐PTA. The platform enables rapid bacterial detection within 5 min, differentiates Gram‐negative from Gram‐positive pathogens, and achieves a low detection limit of 10 CFU/mL.Antônio Oscar Gomes Filho, Alberto Galdino da Silva Júnior, Reginaldo G. Lima‐Neto, Ludovico Migliolo, Maria Danielly Lima de Oliveira, César Augusto Souza de Andrade   +5 morewiley    +1 more source