Results 61 to 70 of about 6,002 (227)

Radiation and immune checkpoint inhibitors in the treatment of oligometastatic non-small-cell lung cancer: a practical review of rationale, recent data, and research questions

Therapeutic Advances in Medical Oncology, 2023
The combined use of stereotactic ablative radiotherapy (SABR) and immune checkpoint inhibitors (ICIs) is an emerging treatment paradigm for oligometastatic non-small-cell lung cancer (NSCLC). Recent phase I and II trial data suggest that SABR to multiple
Sondos Zayed, Alexander V. Louie, Daniel A. Breadner, David A. Palma, Rohann J. M. Correa   +4 more
doaj   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, Volume 19, Issue 11, Page 3023-3034, November 2025.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC

Cancer Immunology, Immunotherapy
Background Stereotactic ablative radiotherapy (SABR) is thought to activate T cell responses in patients with cancer, leading to its combination with immunotherapy and chemotherapy for treatment of non-small-cell lung cancer (NSCLC).
Chao Liu, Yanjuan Chen, Xiaohui Li, Zhijie Bai, Meilin Jiang, Dongsheng Sheng, Wenxue Zou, Rui Huang, Qingyu Huang, Fuhao Wang, Jingyang Zhu, Huiru Sun, Bing Liu, Zongcheng Li, Bing Sun   +14 more
doaj   +1 more source

A multi‐institution performance assessment of a double‐layer MLC

Journal of Applied Clinical Medical Physics, Volume 26, Issue 11, November 2025.
Abstract Background Varian Halcyon and Ethos linacs use a novel double‐layer MLC. Purpose To perform a multi‐institutional characterization of MLC performance of Varian Halcyon and Ethos linacs and establish the range of typical performance indices.
Andy Buckle, Conor Heeney, Matthew Jones, Vasu Ganesan, Ronan Valentine, Philip Wheeler, James Earley, Garry Grogan, Matthew Sparks   +8 more
wiley   +1 more source

Fragility Index analysis for robustness of evidence in Randomized Controlled Trials in National Comprehensive Cancer Network (NCCN) guidelines for rectal cancer

International Journal of Cancer, Volume 157, Issue 9, Page 1864-1875, 1 November 2025.
What's new? Data from randomized controlled trials (RCTs) forms a foundation for rectal cancer treatment guidelines. The reliability of such data is therefore essential for evidence‐based clinical decision‐making. This study assessed the robustness of RCTs cited in the latest National Comprehensive Cancer Network (NCCN) guidelines for rectal cancer ...
Nir Horesh, Justin Dourado, Peter Rogers, Pauline Aeschbacher, Zoe Garoufalia, Rachel Gefen, Ebram Salama, Sameh Hany Emile, Steven D. Wexner   +8 more
wiley   +1 more source

Lobectomy versus stereotactic ablative radiotherapy for medically operable patients with stage IA non‐small cell lung cancer: A virtual randomized phase III trial stratified by age

Thoracic Cancer, 2019
Background Although the choice between stereotactic ablative radiotherapy (SABR) and lobectomy for early‐stage non‐small cell lung cancer (NSCLC) has been debated for years, the two procedures have not yet been directly compared in a randomized trial. We
Young‐Seok Seo, Hak Jae Kim, Hong Gyun Wu, Sun Mi Choi, Samina Park   +4 more
doaj   +1 more source

Transbronchial Cryoablation for Early‐Stage Non‐Small Cell Lung Cancer of the Central Airway Complicated by Idiopathic Pulmonary Fibrosis

Respirology Case Reports, Volume 13, Issue 11, November 2025.
We report the case of an 82‐year‐old man with idiopathic pulmonary fibrosis and central airway squamous cell carcinoma successfully treated with transbronchial cryoablation. The procedure was safe, with no recurrence over 11 months, suggesting its potential as a local treatment alternative to surgery or radiation in patients with lung cancer and ...
Masamitsu Hamakawa, Takashi Niwa, Ryoju Sato, Yasushi Fukuda, Toshihide Yokoyama, Tadashi Ishida   +5 more
wiley   +1 more source

Incidence and risk factors of rhegmatogenous retinal detachment following paediatric cataract surgery: A systematic review and meta‐analysis

Acta Ophthalmologica, Volume 103, Issue 7, Page 764-775, November 2025.
Abstract To determine the incidence and identify risk factors of rhegmatogenous retinal detachment (RRD) following paediatric cataract surgery. This systematic review and meta‐analysis adhered to PRISMA guidelines and was registered in PROSPERO (CRD42024538383). A comprehensive search was conducted across multiple databases, including Cochrane CENTRAL,
Hashem Abu Serhan, Saad Ashraf, Ayesha Shaukat, Ajeet Singh, Hasnaa Abdelrhem, Hamza Irfan, Fariha Arif, Abdullah Ahmed   +7 more
wiley   +1 more source

TP024/#1560  Standard of care therapy with or without stereotactic ablative radiation therapy for recurrent ovarian cancer (SABR-ROC): a prospective randomized phase III trial (KGOG 3064/KROG 2204) [PDF]

, 2023
Chan Woo Wee, So‐Jin Shin, Jae Hong No, Keun Ho Lee, Myong Cheol Lim, Jae‐Weon Kim, Won Kyung Cho, Min Sun Kyung, Jae Yun Song, Kyung‐Jin Min, Eun Ji Lee, Seob Jeon, Jae‐Hoon Kim, Young Seok Kim, Ju‐Won Roh, Jong Hoon Lee, Youngmin Choi, Hyun Ju Kim, Yun Hwan Kim, Yong Bae Kim   +19 more
openalex   +1 more source

Efficacy of stereotactic ablative radiotherapy (SABR) during anti-PD-1 in oligoprogressive non-small cell lung cancer and melanoma—a prospective multicenter observational study pointing out new unmet needs [PDF]

, 2023
P. Damen, Joost J.C. Verhoeff
openalex   +1 more source