Results 51 to 60 of about 32,928 (301)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Rare express saccades in elderly fallers [PDF]

open access: yes, 2008
Q Yang1, T T Lê1, E Debay1, C Orssaud2, G Magnier3, Z Kapoula11Groupe IRIS Vision and Motricité Binoculaire, CNRS, Service d’Ophtalmologie-ORL-Stomatologie; 2Service d’Ophtalmologie, Hôpital Européen Georges Pompidou,
Z Kapoula   +5 more
core  

The role of the ventrolateral frontal cortex in inhibitory oculomotor control [PDF]

open access: yes, 2007
It has been proposed that the inferior/ventrolateral frontal cortex plays a critical role in the inhibitory control of action during cognitive tasks.
James, M   +7 more
core   +1 more source

Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd   +118 more
wiley   +1 more source

Latencies of secondary saccades in adaptation sessions of reactive saccades. [PDF]

open access: yes, 2013
Latency distribution of secondary saccades (first saccades following primary saccades, whether corrective or not) measured in the adaptation sessions of reactive saccades.
Muriel Panouillères (286203)   +3 more
core   +1 more source

Normal Pursuit-System Limitations— First Discovered in Infantile Nystagmus Syndrome

open access: yesJournal of Eye Movement Research, 2013
Infantile nystagmus syndrome (INS) patients occasionally have impaired pursuit. Model and patient data identified relative timing between target motion initiation and INS-waveform saccades as the cause. We used a new stimulus, the “step-pause-ramp” (SPR),
Louis F. Dell’Osso, Jonathan B. Jacobs
doaj   +1 more source

Abnormal Fixational Eye Movements in Amblyopia. [PDF]

open access: yesPLoS ONE, 2016
PURPOSE:Fixational saccades shift the foveal image to counteract visual fading related to neural adaptation. Drifts are slow eye movements between two adjacent fixational saccades.
Aasef G Shaikh   +3 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

Dopamine and impairment at the executive level. [PDF]

open access: yes, 1999
Patients with schizophrenia have an impairment in the inhibition of reflexive saccades, as a consequence of a functional impairment of the prefrontal cortex, which has not yet been encapsulated in terms of a formal model.
Broerse, Annelies   +5 more
core  

Pro-saccades and anti-saccades to onset and offset targets [PDF]

open access: yes, 2005
Pro- and anti-saccades made to either onset or offset targets were examined to determine which of (1) changes in luminance or (2) the appearance of new peripheral objects, is more important in the reflexive generation of pro-saccades. In two experiments,
Pratt, Jay, Trottier, Leo
core   +1 more source

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