Results 81 to 90 of about 45,121 (211)

Invalid Nucleic Acid Test Results May Limit Deceased Donor Organ Utilization

open access: yesTransplant Infectious Disease, EarlyView.
Rare instances occur in which discriminatory NAT results cannot be resolved in deceased organ donor cases. When these events occur the impact on organ donation can be substantial. ABSTRACT Background Nucleic acid testing (NAT) is essential for detecting transmissible viral infections in deceased organ donors and guiding safe organ allocation.
Sara Dionne   +5 more
wiley   +1 more source

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus   +11 more
wiley   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto   +7 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor   +5 more
wiley   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou   +13 more
wiley   +1 more source

Selection of standards for estimated fetal weight percentiles

open access: yesPregnancy, Volume 2, Issue 4, July 2026.
Abstract Objectives To evaluate which of 10 standards or references should be used for determination of percentiles of estimated fetal weight (EFW). Study design Cross‐sectional study using pooled data from four maternal‐fetal medicine (MFM) practices. Inclusion criteria were as follows: ultrasound exam during 2022, singleton fetus, gestational age 240/
C. Andrew Combs   +4 more
wiley   +1 more source

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