Results 171 to 180 of about 77,754 (205)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Rethinking flood resilience: systemic risk, governance failures, and the social production of vulnerability in the Himalayan-Indus region. [PDF]

J Disaster Sci Manag (Singap)
Hamidi AR, Ford JD, Novo P, Paavola J, Malik IH.   +4 more
europepmc   +1 more source

Pierceable, Water‐Resistant, and Transparent Nanofilm Electrodes Comprising Carbon Nanotubes for Long‐Term Monitoring of Plant Electrophysiology

Advanced Science, EarlyView.
Ultra‐flexible electrodes composed of single‐walled carbon nanotubes on a polymeric substrate exhibit excellent transparency, water resistance, and conformability to hairy surfaces. These non‐invasive nanofilms are easily pierced by trichomes, overcoming the structural barriers in plant electrophysiology.
Yusuke Hori, Tatsuhiro Horii, Shinji Masuda, Toshinori Fujie   +3 more
wiley   +1 more source

Examination of hydrological variations and their effect on water shortage trends and water-energy production using convolutional neural network and ISSA. [PDF]

Sci Rep
Liu X, Xuan G, Safarzadeh J.
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

A phenomenological exploration of mental toughness in decision-making: Perceptions from professional Ghanaian footballers. [PDF]

PLoS One
Asamoah B, Boamah Mensah AB, Grobbelaar HW.   +2 more
europepmc   +1 more source

The couple Energy & Engagement Model: a new operational theory for relationship burn-out. [PDF]

Front Psychol
Putois B, Anders R.
europepmc   +1 more source

High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner. [PDF]

FASEB J
Li Y, Fillebeen C, Li S, Chen J, Sweeney G, Pantopoulos K.   +5 more
europepmc   +1 more source

"We're forced to be resilient": exploration of prospective risk and protective factors of resilience among women athletes. [PDF]

Front Sports Act Living
Matheson EL, Varzeas KA, Wesley NY, Rowan M, Becker CB, Ackerman KE, Stewart TM.   +6 more
europepmc   +1 more source

Parental Self-Compassion and Psychological Distress in Families of Children with Language and Speech Disorders: A Mixed-Methods Study in the Greek Context. [PDF]

Children (Basel)
Karakasidou E, Papadimitriou A, Triantafyllou L.   +2 more
europepmc   +1 more source