Results 61 to 70 of about 3,929 (186)

Clinical Features and Treatment Strategies of Li‐Fraumeni Syndrome Patients With Inherited TP53 Mutations

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
LFS with TP53 disease‐causing mutations may be potential beneficiaries of immune checkpoint inhibitors and targeted therapies. Therefore, NGS and PD‐L1 testing should be performed in all LFS patients. ABSTRACT Background Li‐Fraumeni syndrome is a rare autosomal dominant disorder caused by a pathogenic mutation of the tumor suppressor gene TP53.
Keyu Chen, Yufen Xu, Binbin Song, Yuyang Gu, Xiaofang Xu, Jun Cao, Meiyu Fang   +6 more
wiley   +1 more source

Microstructural profiling and habitat analysis to characterize treatment outcome patterns in Sacral Chordomas treated with carbon ions

Medical Physics, Volume 53, Issue 1, January 2026.
Abstract Background Sacral chordoma (SC) is a rare and locally aggressive tumor, characterized by a high risk of local recurrence (LR). Advanced imaging biomarkers capturing tumor heterogeneity and treatment response may help refine patient stratification and improve outcomes.
Letizia Morelli, Giovanni Parrella, Marco Rotondi, Silvia Molinelli, Giuseppe Magro, Sara Imparato, Agnieszka Chalaszczyk, Maria Rosaria Fiore, Chiara Paganelli, Ester Orlandi, Guido Baroni   +10 more
wiley   +1 more source

Primary Mediastinal Seminoma: A Diagnostic and Therapeutic Challenge With an Optimistic Outcome

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
Introduction Primary mediastinal seminoma is a rare germ cell tumor that predominantly affects young men. Clinical presentation is variable, and diagnosis relies on imaging studies, tumor markers, and histopathological confirmation. This case report describes the diagnostic and therapeutic approach in a patient with mediastinal seminoma, in accordance ...
Stephanie dos Santos Bueno, Roberta Borin Previtale, Mike Rocha Alves, Klinger Soares Faico-Filho, Harleen Khatra   +4 more
wiley   +1 more source

Comparative experimental anesthesia efficacy study of epidural injection at the sacrococcygeal space using ultrasound guidance versus blindness technique in Egyptian donkeys (Equus asinus)

BMC Veterinary Research
The study investigates the effectiveness of blind and ultrasound-guided epidural injections in Egyptian donkeys in the sacrococcygeal region, a topic of limited research, by comparing and assessing their onset in 20 healthy adult donkeys of both sexes ...
Mohamed A. Hamed, Hazem Hamouda, Mohammed Elmetwally, Foad Farrag, Mohamed Abdo Rizk, Mohamed M. A. Abumandour, Yamen Mohammed Hegazy, Alaa Samy   +7 more
doaj   +1 more source

Giant Primary Hepatic Endodermal Sinus Tumor: Multidisciplinary Management and Long‐Term Survival

Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.
The endodermal sinus tumor (EST), also known as yolk sac tumor, accounts for 20% of germ cell tumor cases, typically occurring in gonadal locations. However, 1%–5% can present with an extragonadal localization. Primary hepatic EST is an extremely rare entity and poses a diagnostic challenge for the appropriate management of this pathology.
Katia Roque, Rossana Ruiz, Renier Cruz, Andrea Ramirez-Aramburú, Eloy Ruiz, Carlos Castaneda, Marco Galvez-Nino, Ofelia Coanqui, Natalia Valdiviezo, Mivael Olivera Hurtado de Mendoza, Ramon Andrade de Mello, Ilaria Colombo, Luis Mas, Jose I. Mayordomo   +13 more
wiley   +1 more source

Associação de agenesia sacrococcígea e atresia anal em gato sem raça definida Sacrococcygeal agenesis association and anal atresia in mixed breed cats

Ciência Rural, 2009
O presente trabalho teve como objetivo descrever o caso de um felino, que desde o nascimento apresentou atresia anal, ausência de cauda e malformação dos membros pélvicos.
Felipe Purcell de Araújo, Bruno Martins Araújo, Bernardo Kemper, Eduardo Alberto Tudury   +3 more
doaj   +1 more source

Ganglion Impar Neurolysis With 60% Alcohol for Refractory Post‐Traumatic Coccygodynia: A Case Report With Sustained Relief

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT For patients with post‐traumatic coccygodynia refractory to conservative measures, fluoroscopy‐guided ganglion impar neurolysis using 60% alcohol is a highly effective and minimally invasive intervention. This technique should be considered a viable treatment option prior to pursuing more invasive surgical procedures, offering the potential ...
Pradeep Kumar, Ashish Dahal, Sujan Ghimire, Ritika Bhatta   +3 more
wiley   +1 more source

Prenatal Diagnosis of Sacrococcygeal Teratoma Using Two and Three-Dimensional Ultrasonography

Case Reports in Obstetrics and Gynecology, 2012
Sacrococcygeal teratoma accounts for half of all fetal tumors, with a prevalence of 1 : 40,000 births. It is believed to originate from pluripotent cells in Hensen's nodule.
Livia Teresa Moreira Rios, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, Antonio Fernandes Moron, Marília da Glória Martins   +4 more
doaj   +1 more source

Bilateral lung metastases unveils an asymptomatic sacrococcygeal yolk sac tumor

Indian Journal of Pathology and Microbiology, 2017
Sacrococcygeal yolk sac tumor is an uncommon pediatric neoplasm. It usually presents with intra-abdominal or gluteal pain and mass. At later stage, it disseminates to regional nodes and distant organs.
Krishnendu Mondal, Rupali Mandal
doaj   +1 more source

A Rare Foramen at the Base of the Transverse Process of the Fourth Lumbar Vertebra

National Journal of Clinical Anatomy
A 58-year-old male presented with paraplegia of the lower limbs due to a burst fracture of the first lumbar vertebra following a road traffic accident.
Raju Paul Manjooran
doaj   +1 more source