Results 101 to 110 of about 12,722 (192)

Detection of muscular system adverse reaction signals in sacubitril/valsartan treatment combined with statins

Frontiers in Pharmacology
ObjectiveTo detect muscular system adverse reaction signals of sacubitril/valsartan treatment combined with statins (atorvastatin, rosuvastatin, simvastatin) to provide a reference for clinical administration.MethodsMultiplicative and additive models ...
Fukun Zhao, Min Luo, Yuanmin Wang, Mu Su, Fei Tang   +4 more
doaj   +1 more source

The natriuretic peptides system in the pathophysiology of heart failure. From molecular basis to treatment [PDF]

, 2016
After its discovery in the early 1980s, the natriuretic peptide (NP) system has been extensively characterized and its potential influence in the development and progression of heart failure (HF) has been investigated.
Carnovali, Marino, MASTROMARINO, VITTORIA, VOLPE, Massimo   +2 more
core   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

Takotsubo Cardiomyopathy Secondary to Lung Transplantation Followed by Reduced Ejection Fraction Heart Failure: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
A 23‐year‐old male with cystic fibrosis developed Takotsubo cardiomyopathy with left ventricular reduced ejection fraction during bilateral lung transplantation. One year later, he presented with reduced left ventricular ejection fraction and pulmonary edema in the context of medication non‐adherence.
Azadeh Moradkhani, Masoume Avateffazeli, Farah Naghashzadeh, Salman Soleimani, Zargham Hossein Ahmadi, Alireza Jahangiri Fard, Sina Homaee, Mohammad Varahram, Mahshid Hajiali, Shadi Shafaghi, Atefeh Abedini   +10 more
wiley   +1 more source

Role of neprilysin inhibitor combinations in hypertension: insights from hypertension and heart failure trials [PDF]

, 2017
Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.
Bavishi, Chirag, Kadosh, Bernard, Kario, Kazuomi, Messerli, Franz H., Ruilope, Luis M.   +4 more
core  

Congestion, decongestion, renal function and diuretics in (ESC) heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 730-732, April 2025.
Jan Biegus, Piort Gajewski, Piotr Ponikowski   +2 more
wiley   +1 more source

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo, Yi‐Chen Wu, Ji‐Min Li, Tz‐Chuen Ju, Tien‐Sheng Tseng   +4 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF SACUBITRIL AND VALSARTAN IN PHARMACEUTICAL DOSAGE FORM [PDF]

, 2017
Objective: This study aims to develop and validate a stability indicating HPLC method for simultaneous estimation of sacubitril and valsartan in pharmaceutical dosage form.Methods: Sacubitril and valsartan separation were achieved by LC-20 AT C18 (250 mm
Mishra, Shweta, Patel, C. J., Patel, M. M.   +2 more
core   +3 more sources

Sacubitril/valsartan and isolated systolic hypertension in elderly patients: a prospective study

Известия высших учебных заведений. Поволжский регион: Медицинские науки
Background. The purpose of the research is to evaluate the antihypertensive efficacy of sacubitril/valsartan 200 mg/day compared with valsartan 160 mg/day in patients with grade 1–2 isolated systolic arterial hypertension (ISAH).
A.S. Ryazanov, M.V. Makarovskaya, N.A. Anisimov, L.V. Melnikova   +3 more
doaj   +1 more source

Inibitori della neprilisina nel trattamento dell'insufficienza cardiaca : basi farmacologiche ed evidenze cliniche per l'associazione Sacubitril+Valsartan [PDF]

, 2016
Lo scompenso cardiaco è una sindrome multifattoriale nella quale un evento cronico come l'ipertensione, oppure un evento acuto come l'infarto , sono responsabili di alterazioni funzionali che impediscono al cuore di espellere sangue sufficiente da ...
PERONDI, MICHELE
core