Results 261 to 270 of about 20,614 (289)

Reduced congestion and improved response to a fluid/sodium challenge in chronic heart failure patients after initiation of sacubitril/valsartan: The NATRIUM‐HF study

European Journal of Heart Failure
The effects of initiating sacubitril/valsartan in patients with stable heart failure with reduced ejection fraction (HFrEF) on response to fluid and sodium expansion are unknown.
Alexandre Mebazaa, B. Davison, J. Biegus, C. Edwards, Gillian Murtagh, Christos Varounis, H. Hayrapetyan, H. Sisakian, V. R. Ter-Grigoryan, Koji Takagi, Maria Novosadova, P. Ponikowski, G. Cotter   +12 more
semanticscholar   +1 more source

Cardiovascular‐kidney‐metabolic overlap in heart failure with preserved ejection fraction: Cardiac structure and function, clinical outcomes, and response to sacubitril/valsartan in PARAGON‐HF

European Journal of Heart Failure
Cardiovascular‐kidney‐metabolic (CKM) multimorbidity is prevalent among individuals with heart failure (HF), but whether cardiac structure and function, clinical outcomes, and treatment response to sacubitril/valsartan vary in relation to CKM status is ...
Mats C.H. Lassen, J. Ostrominski, B. Claggett, M. Packer, M. Zile, A. Desai, A. Shah, M. Cikes, B. Merkely, M. Gori, Xiaowen Wang, Sheila M. Hegde, M. Pfeffer, M. Lefkowitz, J. McMurray, Scott D. Solomon, M. Vaduganathan   +16 more
semanticscholar   +1 more source

Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF

Circulation
BACKGROUND: A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-β peptides in the brain, some of which are neurotoxic and linked to Alzheimer ...
P. Dewan, Li Shen, João Pedro Ferreira, P. Jhund, I. Anand, Alvin Chandra, L. Chiang, B. Claggett, A. Desai, J. Gong, C. S. Lam, M. Lefkowitz, A. Maggioni, Felipe Martinez, M. Packer, M. Redfield, Jean L. Rouleau, D. V. van Veldhuisen, F. Zannad, M. Zile, Scott D. Solomon, J. McMurray   +21 more
semanticscholar   +1 more source

Long‐Term Outcomes of Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction and Coexisting End‐Stage Renal Disease

Clinical pharmacology and therapy
Sacubitril/valsartan (Entresto) has proven therapeutic effects in heart failure (HF) patients, but its impact on those with advanced chronic kidney disease (CKD) remains unclear, particularly in HF patients with coexisting end‐stage renal disease (ESRD).
Wan-Ying Lin, Y. Shao, Andy F Chiang, Chih-Chieh Huang, Chiang F. Kim, Chao-Shun Chan, Chun-Yao Huang, Bu-Yuan Hsiao   +7 more
semanticscholar   +1 more source

Sacubitril/valsartan

Reactions Weekly, 2022
  +7 more sources

Sacubitril/valsartan

Reactions Weekly, 2018
  +7 more sources

Effects of sacubitril/valsartan according to background beta‐blocker therapy in patients with heart failure and reduced ejection fraction: Insights from PARADIGM‐HF

European Journal of Heart Failure
Beta‐blockers may inhibit neprilysin activity and conversely, neprilysin inhibition may have a sympatho‐inhibitory action. Consequently, sacubitril/valsartan may have a greater effect in patients not receiving a beta‐blocker compared to those treated ...
Sharmistha Datta Gupta, Jawad H. Butt, Eoghan G M McMurray, Atefeh Talebi, S. Matsumoto, A. Rizkala, A. Henderson, A. Desai, M. Lefkowitz, M. Packer, Jean L. Rouleau, Scott D. Solomon, K. Swedberg, M. Zile, P. Jhund, J. McMurray   +15 more
semanticscholar   +1 more source

Effects of Sacubitril/Valsartan on All-Cause Hospitalizations in Heart Failure: Post Hoc Analysis of the PARADIGM-HF and PARAGON-HF Randomized Clinical Trials.

JAMA cardiology
Importance Sacubitril/valsartan is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalizations in patients with chronic HF.
Henri Lu, B. Claggett, M. Packer, C. Lam, K. Swedberg, Jean L. Rouleau, M. Zile, M. Lefkowitz, A. Desai, P. Jhund, J. McMurray, Scott D. Solomon, M. Vaduganathan   +12 more
semanticscholar   +1 more source

Sacubitril/valsartan

Reactions Weekly, 2021
  +5 more sources

Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril.

Organic Letters
Herein we have developed a highly practical and efficient one-step coupling protocol for the synthesis of chiral spiro diphosphine ligands, especially for the oxa-spiro diphosphine ligands O-SDP, which showed excellent reactivity and diastereoselectivity
Gen‐Qiang Chen, Renwei Xiao, Xiaobing Ding, Jiang Wang, Baode Ma, Qiwei Lang, Xu-Meng Zhang   +6 more
semanticscholar   +1 more source