Results 91 to 100 of about 645,712 (359)

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Dynamics of Lennard-Jones clusters: A characterization of the activation-relaxation technique

, 2000
The potential energy surface (PES) of Lennard-Jones clusters is investigated using the activation-relaxation technique (ART). This method defines events in the configurational energy landscape as a two-step process: (a) a configuration is first activated
A.F. Voter, A.F. Voter, C. Lanczos, C. Roland, C.J. Cerjan, C.J. Tsai, D.J. Wales, D.J. Wales, F.H. Stillinger, F.M. Bulnes, G.T. Barkema, G.T. Barkema, G.T. Barkema, J. Pancir, J. Pillardy, J. Wang, J.G. Amar, J.P.K. Doye, J.P.K. Doye, L.J. Munro, M. Breeman, M. Breeman, M. Djafari-Rouhani, M. Djafari-Rouhani, M. Djafari-Rouhani, M.R. Hoare, N. Mousseau, N. Mousseau, N. Mousseau, N. Mousseau, Normand Mousseau, Otto F. Sankey, R.H. Leary, Rachid Malek, S. Wilson, W.H. Press   +35 more
core   +1 more source

Cadence Detection in Road Cycling Using Saddle Tube Motion and Machine Learning [PDF]

, 2022
Bernhard Hollaus, Jasper C. Volmer, Thomas Fleischmann   +2 more
openalex   +1 more source

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Bilayer Kagome Borophene with Multiple van Hove Singularities

Advanced Science
The appearance of van Hove singularities near the Fermi level leads to prominent phenomena, including superconductivity, charge density wave, and ferromagnetism.
Qian Gao, Qimin Yan, Zhenpeng Hu, Lan Chen   +3 more
doaj   +1 more source

Development of Saddle Height Control System for Cycle Road Racer based on SEMG Signals of the Leg Muscles

Journal of Biomechanical Science and Engineering, 2013
The saddle height of a cycle road racer influences the competitive performance of the cyclist. Cyclists can adjust the saddle height carefully according to their kinesthetic sense while riding a bicycle. The saddle height control system we have developed
Tatsushi TOKUYASU, Shimpei MATSUMOTO
doaj   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Development of Two Pommel Mushrooms for Men's Artistic Gymnastics

Journal of Physical Education Health and Sport, 2020
The purpose of this research was to see if the two-saddle mold device could be used asa means of training an athlete in overcoming the difficulty of mastering a sirkel movement on the saddle.
Agus Darmawan
doaj   +1 more source

Identifying and attacking the saddle point problem in high-dimensional non-convex optimization [PDF]

, 2014
A central challenge to many fields of science and engineering involves minimizing non-convex error functions over continuous, high dimensional spaces.
Caglar Gulcehre, Kyunghyun Cho, Razvan Pascanu, Surya Ganguli, Universite ́ De Montréal, Yann N. Dauphin, Yoshua Bengio   +6 more
core  

Monotonicity of saddle maps

, 2018
We prove an analog of Schoen--Yau univalentness theorem for saddle maps between discs.Comment: 9 pages, 3 ...
Petrunin, Anton, Stadler, Stephan
core   +1 more source