Results 81 to 90 of about 275,215 (238)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Research on similarity test design and characteristic verification for tank fires under environmental wind conditions.

open access: yesPLoS ONE
Petroleum is recognized as a crucial strategic material for national sustainable development, and its safe storage, transportation, and utilization have significant impacts on the human ecological environment. In order to conduct in-depth research on the
Yi Jiang   +3 more
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

open access: yesAdvanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao   +11 more
wiley   +1 more source

Hazard Contribution Modes of Machine Learning Components [PDF]

open access: yes
Amongst the essential steps to be taken towards developing and deploying safe systems with embedded learning-enabled components (LECs) i.e., software components that use ma- chine learning (ML)are to analyze and understand the con- tribution of the ...
Denney, Ewen   +2 more
core   +1 more source

Extension of the C-XSC Library with Scalar Products with Selectable Accuracy [PDF]

open access: yes, 2010
The C++ class library C-XSC for scientific computing has been extended with the possibility to compute scalar products with selectable accuracy in version 2.3.0. In previous versions, scalar products have always been computed exactly with the help of the
Bohlender, Gerd   +3 more
core  

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

open access: yesAdvanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint   +6 more
wiley   +1 more source

Analysis of Present State of the Digital Power Meter Field Calibration Technology

open access: yesMATEC Web of Conferences, 2016
As one of the most important measurement equipment of the intelligent substation, digital electric energy meter fundamentally resolved the technical bottleneck of traditional substation.
Xu Yi-Hui, Li Zhen-hua
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao   +8 more
wiley   +1 more source

Multilayer Soft Photonic Arrays Inspired by Cephalopod Skin for High‐Density, Independent, and Multimodal Actuation

open access: yesAdvanced Functional Materials, EarlyView.
A vertically stacked, DEA‐driven photonic array inspired by cephalopod skin, featuring highly crystalline colloidal crystal gels with vivid color, low FWHM and scalability is presented. The multilayer design removes lateral pixel interference, achieving near‐100% fill factor with fully independent RGB actuation.
Maga Kim   +11 more
wiley   +1 more source

Clinical outcomes of Transepithelial photorefractive keratectomy to treat low to moderate myopic astigmatism

open access: yesBMC Ophthalmology, 2018
Background To evaluate the refractive and visual outcomes of Transepithelial photorefractive keratectomy (TransPRK) in the treatment of low to moderate myopic astigmatism.
Lei Xi, Chen Zhang, Yanling He
doaj   +1 more source

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