Results 51 to 60 of about 1,100,636 (280)

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Testing safe haven properties of digital and financial assets: wavelet coherence insights from G7 banking sector indices during crises

Humanities & Social Sciences Communications
This paper employs the wavelet coherence approach to examine the dynamic time-frequency relationships among Bitcoin, gold, gold-backed crypto assets (DGX and PAXG), and G7 banking sector indices during major global crises, including the COVID-19 outbreak,
Yasmine Snene Manzli, Naif Alsagr, Ahmed Jeribi   +2 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Abortion and Safe Haven Laws [PDF]

, 2022
Notwithstanding the assertions of the State of Mississippi, of one amicus, and of Justice Amy Coney Barrett in Dobbs v. Jackson Women’s Health Organization, abortion laws and safe haven laws are oil and vinegar.
Parness, Jeffrey A.
core   +1 more source

Verifying and Ranking Safe-Haven Assets under Different Sources of Shocks: Evidence from a Quantile-Based Triple-Check Framework

East Asian Economic Review
This paper examines the safe-haven properties of the Japanese yen (JPY), Bitcoin (BTC), gold, and the 10-year U.S. Treasury (UST10Y) under comparable tail-risk conditions.
Han Yan, Heejoon Han
doaj   +1 more source

Portfolio Management in Times of Elevated Risk. Safe-Haven and Hedge Assets in CAPM Setting

Finanse i Prawo Finansowe
The purpose of the article. The purpose of the article is to present the safe-haven concept according to the latest academic literature and distinguish it from the hedge and diversifier terms that are sometimes used interchangeably by researchers and ...
Ewa Feder-Sempach
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Flight-to-Safety und Safe-Haven-Assets : Ein Entwurf eines Safe-Haven-Indikators

, 2021
In einem unsicheren Marktumfeld tendieren Investor*innen dazu, durch Investitionen in bestimmte Anlagen einen sicheren Hafen aufzusuchen. Ein Indikator, der nun in der Lage ist, die Nachfrage der Investor*innen nach diesen als sicher geltenden Anlagen ...
Haidenthaler, Julian
core   +2 more sources

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source