Results 71 to 80 of about 5,157,791 (303)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Safe-arm initiator Patent [PDF]
, 1970 Electroexplosive safe-arm initiator using electric driven electromagnetic coils and magnets to align ...
Parker, L. C.
core +1 more source
Prioritization of hazards by means of a QFD-based procedure [PDF]
, 2018 Despite the evolution of regulations in the field of occupational health and safety promoted in EU countries, the number of accidents and victims has not significantly decreased in recent years, especially in constructions and agriculture sectors, as ...
Fargnoli, Mario, Lombardi, Mara
core +1 more source
Jornal de Pediatria, 2005 To review the strategies to make school a safe environment. The paper first addresses the social context of accidents and violence in the school environment, and makes recommendations, based on the literature data, for the implementation of safe schools.Articles published between 1993 and 2005 in the MEDLINE database.
Edson Ferreira, Liberal +3 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Emerging Trends of Safe Working Conditions in the Construction Industry: A Bibliometric Approach
BuildingsThe construction industry has been slow to implement safe working conditions, even though it could reduce the risks and dangers that the industry’s operations pose to human health and safety.
Ayodele Oluwole Alejo +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
THE USE OF CAD METHODS FOR DESIGNING BLOWOUT PREVENTERS BOP IN OIL INDUSTRY [PDF]
Fiabilitate şi Durabilitate, 2014 Best practice design and analysis of operational safety requires CAD modeling of these BOP.The primary objective for this paper was to design and select a suitable BOP system to meet the applications and proposing CAD solutions to improve the operation
Marius STAN
doaj