Results 261 to 270 of about 3,072,572 (310)
Some of the next articles are maybe not open access.
Safety assessment of a new multivitamin
Food and Chemical Toxicology, 2012A newly created multivitamin possesses many protective health functions. To investigate its safety when applied in medical treatment and when used as a food supplement, we studied its acute oral toxicity and 13-week oral toxicity in mice. The results showed that the oral lethal dose, 50% (LD(50)) of the biomass of the multivitamin in mice was greater ...
Jun, Tao +6 more
openaire +2 more sources
Toxicogenomics in Drug Safety Assessment
Pharmacogenomics, 2008Molecular investigative toxicology is an approach that the pharmaceutical industry has started to take more seriously in order to improve the drug discovery and development process, with the overall goal to reduce attrition. By combining traditional toxicology approaches with the development, validation and implementation of new technologies such as ...
Philip, Hewitt, Alexandra, Walijew
openaire +2 more sources
Independent Safety Assessment of Safety Arguments
2007The paper describes the role of Independent Safety Auditor (ISA) as carried out at the present in the defence and other sectors in the UK. It outlines the way the ISA role has developed over the past 15–20 years with the changing regulatory environment. The extent to which the role comprises audit, assessment or advice is a source of confusion, and the
openaire +1 more source
The safety assessment of fragrance materials
Regulatory Toxicology and Pharmacology, 2003Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials ...
David R, Bickers +8 more
openaire +2 more sources
2020
In most clinical trials in phase II and III, the primary endpoint measures efficacy and therefore sample size calculation is based on this outcome. However, there are also situations were the primary objective concerns safety. Furthermore, even if sample size calculation is based on an efficacy endpoint, one is commonly interested which extent of ...
openaire +1 more source
In most clinical trials in phase II and III, the primary endpoint measures efficacy and therefore sample size calculation is based on this outcome. However, there are also situations were the primary objective concerns safety. Furthermore, even if sample size calculation is based on an efficacy endpoint, one is commonly interested which extent of ...
openaire +1 more source
The assessment of drug safety for the fetus
International Journal of Clinical Pharmacy, 2020Long standing concerns regarding the use of medications during pregnancy and their unknown effects on fetal development and child health suggests the need for modified study methods regarding the establishment of drug safety for the fetus. This Current Commentary highlights several pharmacological study method limitations and offers suggestions for the
openaire +2 more sources
Safety assessment of Cordyceps guangdongensis
Food and Chemical Toxicology, 2010Cordyceps guangdongensis as a kind of fungus, has been discovered and cultivated successfully in recent years. However, its safety assessments have not been studied. In this report, a serial of tests for toxicological safety assessments were depicted in details. These tests included bacterial reverse mutation (Ames) study, bone marrow cell micronucleus
Wen-juan, Yan +4 more
openaire +2 more sources
Software Safety Assessment and Probabilities
2016 46th Annual IEEE/IFIP International Conference on Dependable Systems and Networks Workshop (DSN-W), 2016In a context where software is more and more pervasive in all systems, and where it is sometimes advocated that software complexity and size seem to provide some relevance to a probabilistic view of software behaviour, several initiatives suggest to change the way to address software in the global system safety assessment.
Jean-Paul Blanquart +9 more
openaire +1 more source
An Assessment of Statin Safety by Nephrologists
The American Journal of Cardiology, 2006Recently, concerns regarding potential adverse effects of the statins on the kidney have been raised. The Kidney Expert Panel of the National Lipid Association's (NLA) Safety Task Force, made up of 3 nephrologists, was convened to review all of the currently available evidence pertinent to determining whether statins cause kidney injury, independent of
Bertram L, Kasiske +2 more
openaire +2 more sources
The Definition and Assessment of a Safety Argument
2014 IEEE International Symposium on Software Reliability Engineering Workshops, 2014That safety cases are gaining prominence in safety regimes and regulations is a claim that, nowadays, may go more or less unchallenged. In brief, a safety case intends to make an explicit and compelling case that a system under consideration is safe for its intended use.
Valentin Cassano, T. S. E. Maibaum
openaire +1 more source