Results 41 to 50 of about 1,010,797 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparative study on the application of human milk oligosaccharides in infant and young children formula food

Zhongguo shipin weisheng zazhi
Human milk oligosaccharides （HMOs） are the key bioactive components in breast milk， which have multiple functions such as promoting brain development， regulating immune system and maintaining intestinal health.
WANG Guo, LI Huzhong, CAO Chongjiang, LIU Sana, DUAN Xiaosa, FANG Haiqin   +5 more
doaj   +1 more source

Establishment of probability assessment parameters of consumption of alcoholic beverage based on the contact area

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo support the probabilistic assessment of food contact materials with consumption parameters and methodology， the establishment of consumption data based on food contact area with different types of alcoholic beverages and different food ...
LI Shan, WANG Yibaina, YANG Daoyuan, LI Jianwen, PAN Feng, SUI Haixia   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Typing methods based on whole genome sequencing data

One Health Outlook, 2020
Whole genome sequencing (WGS) of foodborne pathogens has become an effective method for investigating the information contained in the genome sequence of bacterial pathogens.
Laura Uelze, Josephine Grützke, Maria Borowiak, Jens Andre Hammerl, Katharina Juraschek, Carlus Deneke, Simon H. Tausch, Burkhard Malorny   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Research on hazard assessment of butyl benzyl phthalate

Zhongguo shipin weisheng zazhi
ObjectiveTo systematically evaluate the toxic effects and potential health hazards of butyl benzyl phthalate （BBP）， thereby providing a scientific basis for its risk management and control.MethodsLiterature published in both Chinese and English before ...
TIAN Yaru, ZHANG Qiannan, ZHUANG Zhisen, WANG Yuxin, WANG Xiaohong, SUI Haixia, YANG Hui, JIA Xudong   +7 more
doaj   +1 more source

Immunophenotyping: Application to Safety Assessment [PDF]

Toxicologic Pathology, 2017
A continuing education course entitled “What You Always Wanted to Know About Immunotoxicology in Pharmaceutical Development…But Were Afraid to Ask” was offered at the Society of Toxicologic Pathology (STP) 36th annual symposium in Montreal. This article summarizes some key points made during the presentation dedicated to immunophenotyping. It describes
Xiaoting, Wang, Hervé, Lebrec
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Prevalence, antibiotic susceptibility, and genomic analysis of Vibrio alginolyticus isolated from seafood and freshwater products in China

Frontiers in Microbiology
IntroductionThis study characterized Vibrio alginolyticus isolated from seafood and freshwater products in China (2020).Methods and ResultsIn total, 122 (95.31%) V.
Yanan Sun, Yanan Sun, Yanfei Yan, Shaofei Yan, Fengqin Li, Ying Li, Lin Yan, Dajin Yang, Zixin Peng, Baowei Yang, Jiali Sun, Jin Xu, Yinping Dong, Yao Bai   +13 more
doaj   +1 more source