Results 41 to 50 of about 2,559,900 (249)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Evaluation of segmentation accuracy and the improvement of time effectiveness using deep learning-based segmentation in 177Lu-DOTATATE dosimetry

EJNMMI Physics
Background The efficacy of deep learning-based artificial intelligence segmentation (AI-seg) in 177Lu-DOTATATE dosimetry remains underexplored. This study evaluates AI-seg’s contouring accuracy, dosimetric reliability, and time efficiency.
Tetsu Nakaichi, Yuhei Shimizu, Satoshi Nakamura, Yasunori Shuto, Yusaku Kasai, Atsushi Shishido, Kouji Kunito, Hiroki Nakayama, Mihiro Takemori, Masashi Kawamura, Takahito Chiba, Hiroyuki Okamoto, Tairo Kashihara, Hiroshi Igaki, Kimiteru Ito   +14 more
doaj   +1 more source

Building a Robust Scenario Library for Safety Assurance of Automated Driving Systems: A Review

IEEE Access
Ensuring the safety of Automated Driving Systems (ADSs) is both a critical and complex endeavor. The increasing demand for autonomous driving technologies underscores the importance of robust safety assurance, yet the intricate nature of these systems ...
Antonio A. Bruto da Costa, Patrick Irvine, Tudor Dodoiu, Siddartha Khastgir, Paul Jennings   +4 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Safety cases for the formal verification of automatically generated code

, 2010
Model-based development and automated code generation are increasingly used for actual production code, in particular in mathematical and engineering domains.
Basir, Nurlida
core   +1 more source

A Holistic Integral Safety Assurance Approach to Aircraft Digital System Development Process

Engineering Proceedings
The maturation of system engineering practices to support the regulatory landscape and handle novel application domains, such as hybrid-electric distribution systems, calls for new ways to support development assurance objectives and end-to-end safety ...
Loris Dal Lago, Janet J. Liu
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Long-Term Care Quality Assurance Policies in the European Union. ENEPRI Research Report No. 111, March 2012 [PDF]

, 2012
This report analyses the quality assurance policies for long-term care (LTC) in the following countries: Austria, Estonia, Finland, France, Germany, Hungary, Italy, Latvia, Poland, Slovakia, Slovenia, Spain, Sweden, the Netherlands, and the United ...
Pelone, Ferruccio, Avolio, Maria, Casanova, Georgia, Dandi, Roberto, De Belvis, Antonio Giulio, Volpe, Massimo   +5 more
core  

Research progress on operation safety assurance technologies for double-layer lined water conveyance tunnels

Shuili Shuiyun Gongcheng Xuebao
Water conveyance tunnels are vital infrastructure in major water diversion projects, playing a key role in ensuring the project’s water supply capacity. To overcome the limitations of traditional single-layer linings—such as insufficient anti-seepage and
HU Jiang, LIANG Yu, HU Jingyu, LI Xing
doaj   +1 more source