Results 91 to 100 of about 6,526,626 (301)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Ohio Highway Safety Program annual evaluation report

open access: yes
Description based on: Federal fiscal year 2004; title from cover of PDF document (viewed Feb. 1, 2006)
Ohio. Governor's Highway Safety Office.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Thermal regulation and frost control of subgrade by a ground source heat pump system

open access: yesCase Studies in Thermal Engineering
In response to subgrade frost heave damage in cold regions, an active heating method that utilizes geothermal energy is proposed. By using ground source heat pump technology, a dedicated heat regulation system and a distributed heating scheme are ...
Tianfei Hu   +6 more
doaj   +1 more source

Mechanism investigation of scratch-induced ductile damage in brittle polylactic acid revealed by in situ observation [PDF]

open access: yesNanotechnology and Precision Engineering
Polylactic acid (PLA) is widely utilized across various fields for its excellent biocompatibility and mechanical properties. However, inevitable sharp-object contacts cause surface scratches, hindering performance optimization, owing to the poorly ...
Zhongmeng Zhu   +4 more
doaj   +1 more source

Amish buggy safety status report, Ohio Department of Public Safety

open access: yes, 2000
Title from cover of PDF document (viewed Jan. 31, 2006).; "May 2000."; Harvested from the web on 2/6/06This report reflects the results of a yearlong joint project undertaken by the Ohio departments of Public Safety (ODPS) and Transportation (ODOT).

core  

Safety climate and the theory of planned behavior: towards the prediction of unsafe behavior [PDF]

open access: yes, 2010
The present study is concerned with the human factors that contribute to violations in aviation maintenance. Much of our previous research in this area has been based on safety climate surveys and the analysis of relations among core dimensions of ...
Shaw, Andrew, Fogarty, Gerard J.
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

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