Results 71 to 80 of about 8,058,247 (342)

SWISS CHEESE IN BRAZIL: DISASTER CULTURE AND SAFETY CULTURE IN DISASTERS [PDF]

Ambiente & Sociedade
This article discusses points related to “disaster culture” and “safety culture” in Brazil, and debates how societal-structural factors influence the management of low incidence and high consequence disasters, such as dam breaks, which appear to provide ...
JEROEN WARNER, ELIZABETH NUNES ALVES, ROBERT COATES   +2 more
doaj   +4 more sources

Audits and inspections are never enough: a critique to enhance food safety [PDF]

, 2013
Internal and external food safety audits are conducted to assess the safety and quality of food including on-farm production, manufacturing practices, sanitation, and hygiene. Some auditors are direct stakeholders that are employed by food establishments
Chapman, Benjamin J., Costa, Roy E., Dodd, Charles, Morley, Katija A., Paterno, Maria Sol Erdozain, Powell, Douglas A.   +5 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of Safety Culture among Healthcare Workers in Borujerd [PDF]

Muhandisī-i bihdāsht-i ḥirfah/ī, 2023
Background and Objective: A proper safety culture is one of the important factors that ensure a healthy and safe work environment. In order to ensure safety performance in the workplace, healthcare departments are required to establish safety rules and ...
Hamed Ahmadpour, Younes Mohammadi, Iraj Mohammad Fam, Mostafa Mirzai Aliabadi   +3 more
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Safety Culture Among the Employees of the Operational Units of South Zagros Oil & Gas Production Company, Iran

Health in Emergencies & Disasters Quarterly, 2022
Background: Safety plays a significant role in the oil & gas industries, where there are many risk factors that can cause accidents. This study aims to evaluate the level of safety culture among the employees of the operational units of South Zagros Oil &
Mohammad Reza Omidi, Meysam Jafari Eskandari, Nabi Omidi   +2 more
doaj  

Safety climate perceived by pre-hospital emergency care personnel—an international cross-sectional study

Frontiers in Public Health, 2023
IntroductionImproving patient safety is one of the most critical components of modern healthcare. Emergency medical services (EMS) are, by nature, a challenging environment for ensuring patient safety.
Justyna Kosydar-Bochenek, Dorota Religa, Małgorzata Knap, Marcin Czop, Bartosz Knap, Bartosz Knap, Wioletta Mędrzycka-Dąbrowska, Sabina Krupa   +7 more
doaj   +1 more source

Providing Feedback Following Leadership Walkrounds is Associated with Better Patient Safety Culture, Higher Employee Engagement and Lower Burnout [PDF]

, 2017
Background There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance.
Adair, Kathryn C., Bogan, Brittany, Frankel, Allan S., Frankel, Terru Christensen, Jamal, Maleek, Leonard, Michael W., Magnus, Brooke E., Proulx, Joshua, Schwendimann, Rene, Sexton, J. Bryan, Watson, Sam R.   +10 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source