Results 1 to 10 of about 3,112,326 (355)

Safety Evaluation of Curcumol by a Repeated Dose 28-Day Oral Exposure Toxicity Study in Rats

Toxics, 2023
Curcumol, a natural product isolated from the traditional Chinese medicine Rhizoma curcumae, possesses various potential therapeutic values in many diseases. However, evidence of its toxicological profile is currently lacking.
Zhaoxu Yang, Sheng Wang, Yawen Hong, Renhua Gai, Wenxiang Hong, Bingbing Tang, Chunqin Lin, Xiaomeng Wang, Qiaojing Wang, Chao Chen, Jiajia Wang, Qinjie Weng   +11 more
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Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice

Frontiers in Cell and Developmental Biology
BackgroundStem cell therapy shows promise for treating skin diseases and enhancing medical aesthetics. However, safety data for subcutaneous injection of stem cells remain limited.
Lijuan Xia, Jinjin Shao, Qian Yang, Chengda Zhang, Zhiqi Xie, Linying Wang, Cong Xu, Siming Zhang, Jing Liu, Jing Liu, Fang Liu, Fang Liu, Yuhua Shi, Liqiang Gu, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang, Lijiang Zhang   +23 more
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Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis

Stem Cell Research & Therapy
Background Atopic dermatitis (AD) management is significantly challenging due to the high prevalence, chronicity, and recurrent nature of the disease, and limited options for its treatment.
Jinjin Shao, Zhiqi Xie, Zhichao Ye, Guoyu Chen, Yiru Wang, Lili Zhang, Fang Liu, Siming Zhang, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang   +16 more
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Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores

Frontiers in Cell and Developmental Biology
IntroductionGanoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological ...
Junxiu Liu, Yisheng Song, Yisheng Song, Chuanhuai Chen, Jing Liu, Jing Liu, Siming Zhang, Fang Liu, Fang Liu, Ruiyu Tian, Jinjin Shao, Lili Zhang, Tingli Bian, Ruimin Sun, Li Yu, Shuizhen Pan, Yunxiang Chen, Yaoxian Xuan, Hanbo Wang, Zhenhao Li, Ying Chen, Lijiang Zhang, Lijiang Zhang   +22 more
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Bio-distribution and toxicity potential of human umbilical cord mesenchymal stem cells in cynomolgus monkeys

Scientific Reports
Mesenchymal stem cells (MSCs) have demonstrated promising advantages in the therapies of many diseases, while its multi-directional differentiation potential and immunotoxicity are the major concerns hindered their clinical translation.
Ying Huang, Xiaofang Hao, Zhi Lin, Lulu Li, Hua Jiang, Hezhan Zhang, Xingchao Geng, Hao Zhu, Hairuo Wen   +8 more
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Corrigendum to Evaluation of the Safety of Rapid Administration of Undiluted High-Dose Intravenous Levetiracetam [PDF]

, 2022

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Peripheral serum iTRAQ-based proteomic characteristics of carbon tetrachloride-induced acute liver injury in Macaca fascicularis

Toxicology Reports
Carbon tetrachloride (CCl4) is a potent chemical compound that can induce liver cells necrosis. The purpose of this study was to evaluate the hepatic toxicity of CCl4 exposure in Macaca fascicularis to explore the liver toxicity mechanism using a ...
Miao Yufa, Chen Dongmei, Li Wei, Li Shuangxing, Sun Li, Geng Xingchao   +5 more
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Study on the 90-day Feeding Experimental Background Data of SD Rats for Drug Safety Evaluation

Shiyan dongwu yu bijiao yixue
ObjectiveTo establish background data for a 90-day feeding trial of SD rats to ensure the reliability of research data.MethodsBackground data from six independent 90-day feeding trials of SD rats conducted by the National Center for Safety Evaluation of ...
QIN Chao, LI Shuangxing, ZHAO Tingting, JIANG Chenchen, ZHAO Jing, YANG Yanwei, LIN Zhi, WANG Sanlong, WEN Hairuo   +8 more
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Evaluation of the impacts of occupational health and safety management of international firms in developing countries

, 2022
Tall Dia Matam
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Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

Frontiers in Cellular and Infection Microbiology
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had given rise to a massive epidemic. Owing to the high morbidity and mortality of COVID-19 and the lack of effective therapies, safe and effective
Ruimin Sun, Ruimin Sun, Lijuan Xia, Lijuan Xia, Guangbiao She, Guangbiao She, Jinrong Li, Yiru Wang, Yiru Wang, Yunxiang Chen, Yunxiang Chen, Qian Yang, Siming Zhang, Fang Liu, Ying Chen, Liyan Zhang, Chengda Zhang, Wanqiang Lv, Wanqiang Lv, Enqi Huang, Enqi Huang, Lijiang Zhang, Lijiang Zhang, Lijiang Zhang   +23 more
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