Results 301 to 310 of about 3,112,326 (355)
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Safety evaluation of telbivudine
Expert Opinion on Drug Safety, 2010Successful treatment of chronic hepatitis B (CHB) often requires long-term oral nucleoside/nucleotide agents which can be associated with viral resistance, patient non-compliance and adverse effects. Telbivudine is one of the more potent options available, with a 6.5- to 6.6-log copies/ml hepatitis B DNA reduction at 12 weeks in an early viral kinetic ...
Fung, J, Yuen, MF, But, DYK, Lai, CL
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Safety evaluation of benzophenone
Food and Chemical Toxicology, 1991Benzophenone (FEMA No. 2134; CAS No. 119-61-9) was administered in the diet to rats at target dose levels of 20 mg/kg body weight/day for 90 days and 100 or 500 mg/kg/day for 28 days. Body weights and food consumption were measured weekly; haematology, clinical chemistry and urinalysis values were obtained at 4 wk and at the end of the study. Gross and
G A, Burdock, D H, Pence, R A, Ford
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Safety evaluation of preservatives
International Journal of Cosmetic Science, 1997Les conservateurs sont ajoutes aux produits cosmetiques pour augmenter leur duree de vie, en les protegeant contre une contamination microbienne qui sans cela les degraderait et exposerait le consommateur a un danger d'infection. Malgre tout, les conservateurs sont des produits chimiques biologiquement actifs qui exposent aussi le consommateur a des ...
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Macronutrient substitutes: Safety evaluation
Regulatory Toxicology and Pharmacology, 1992Macronutrient substitutes, reduced-calorie substances used to replace organoleptic and/or functional properties of fats and sugars in the diet, may become a significant part of the diet as the trend toward lower fat and lower calorie diets continues. Procedures currently used to evaluate the safety of traditional food additives (microadditives) may be ...
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Challenges of safety evaluation
Journal of Ethnopharmacology, 2014Each application for authorisation of a medicinal product must be accompanied by the particulars and documents referred to in Directive 2001/83/EC on the Community code relating to medicinal products for human use. Details on the documentation needed for traditional herbal medicinal products (THMP) are given in article 16c of the above mentioned ...
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Safety Evaluation of Pesticides
Journal of the Forensic Science Society, 1975The need for safeguards against contamination by pesticides is considered. The present controls on these substances are examined, with particular reference to the Pesticides Safety Precaution Scheme and its requirements.
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Medical Laser Safety Hazard Evaluation
Health Physics, 2002Health care laser systems offer general laser hazards and additional specific concerns unique to the clinical environment. A formal laser hazard evaluation procedure provides an efficient mechanism for identifying potential laser safety hazards. This paper outlines such a medical laser hazard evaluation program and highlights the unique characteristics
Ben E, Edwards +3 more
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Drug safety evaluation of defibrotide
Expert Opinion on Drug Safety, 2012Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of chemotherapeutic conditioning used in preparation for hematopoietic stem-cell transplantation (SCT). Defibrotide (DF) has been shown in Phase II and III trials to improve complete response in patients with severe ...
Paul G, Richardson +13 more
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Safety evaluation of hydrogenated oils
Food and Chemical Toxicology, 1990Processed foods have become an important part of the diet in industrialized countries. Advances in technology have brought about significant changes in the production methods in the food industry and have led to an improvement in texture, colour, shelflife and taste of conventional food products and to the development of novel foods.
P M, Verschuren, J L, Zevenbergen
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