Results 91 to 100 of about 3,444,701 (305)

Challenges and Innovations in Pharmacovigilance and Signal Management During the COVID-19 Pandemic: An Industry Perspective

Vaccines
Vaccine marketing authorization holders (MAHs) are responsible for the conduction of global vaccine pharmacovigilance on their vaccine products. A safety signal is detected when a new adverse event (AE) or aspect of an AE occurs after exposure to the ...
Maria Maddalena Lino, Susan Mather, Marianna Trani, Yan Chen, Patrick Caubel, Barbara De Bernardi   +5 more
doaj   +1 more source

Management of threats and errors in normal operations of assistant controllers : a thesis presented in partial fulfilment of the requirements for the degree of Master in Aviation at Massey University [PDF]

, 2007
"To err is indeed human, so to err is normal" Human errors are usually pronounced in accident or incident reports. Seldom does one pay enough attention to these errors during daily normal operations as these either go unnoticed or unreported for ...
Yeung, Timothy Kwan Chi
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Assessing and Optimizing Urban Dynamic Resilience to Extreme Rainfall from Shock to Recovery

International Journal of Disaster Risk Science
Climate change has intensified extreme rainfall events, challenging progress toward SDG 11’s urban resilience targets. Current assessment methods often neglect dynamic recovery processes and regional precipitation disparities.
Linmei Zhuang, Ming Wang, Kai Liu, Loon Ching Tang, Jidong Wu, Dingde Xu, Junfei Liu, Jiawang Zhang, Jiarui Yang, Yi Ren, Dong Xu   +10 more
doaj   +1 more source

Dynamic triaxial constitutive model for rock subjected to initial stress

Open Physics, 2020
Building on the existing model, an improved constitutive model for rock is proposed and extended in three dimensions. The model can avoid the defect of non-zero dynamic stress at the beginning of impact loading, and the number of parameters is in a ...
Li Junzhe, Zhang Guang, Liu Mingze, Hu Shaohua, Zhou Xinlong   +4 more
doaj   +1 more source

Improving health and public safety through knowledge management [PDF]

, 2004
This paper reports on KM in public healthcare and public safety. It reflects the experiences of the author as a CIO (Chief Information Officer) in both industries in Australia and New Zealand. There are commonalities in goals and challenges in KM in both
Soar, Jeffrey
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Health and safety in the United Kingdom higher education libraries: a review of the literature [PDF]

, 2011
The focus of this article is to review the literature relating to health and safety in UK Higher Education libraries. This will include an overview of the literature on accident theories and also the human element.
MacLean, Alison
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Numerical simulation study on the damage characteristics of water jet impact in drill holes with gangue coal rock

Scientific Reports
In the context of coal mining, where gas problems are prevalent, water jet penetration enhancement technology has emerged as a critical solution for improving gas extraction.
Yabin Gao, Shaoqi Zhang, Junyu Hong, Jing Cao, Mengbo Li   +4 more
doaj   +1 more source